奥曲肽联合埃索美拉唑对十二指肠溃疡合并出血患者的疗效  

Curative effect of octreotide combined with esomeprazole in patients with bleeding duodenal ulcer

作　　者：申妮[1] 张永利 刘鹏飞[1] 薛顺和 乔丽娜 

机构地区：[1]延安大学附属医院消化内科,陕西延安716000 [2]陕西省铜川市人民医院(南院)内三科,727100 [3]陕西省延安市中医医院急诊科,716000

出　　处：《检验医学与临床》2017年第21期3201-3202,3205,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨奥曲肽联合埃索美拉唑对十二指肠溃疡合并出血患者平均出血率、再出血率及不良反应的影响。方法选取延安大学附属医院2014年5月至2016年5月收治的十二指肠溃疡合并出血患者80例,随机选取40例患者分为单纯埃索美拉唑治疗组(单独治疗组),另40例为奥曲肽联合埃索美拉唑治疗组(联合治疗组),对2组患者的临床疗效、出血情况、再出血率、平均止血时间、不良反应发生情况进行统计分析。结果联合治疗组患者治疗的总有效率为97.5%,明显高于单独治疗组的80.0%,差异有统计学意义(P<0.05);联合治疗组出血率、再出血率为5.0%、0,均明显低于单独治疗组的15.0%、5.0%,差异有统计学意义(P<0.05);联合治疗组平均止血时间明显短于单独治疗组,差异有统计学意义(P<0.05);2组患者的不良反应发生率均为10.0%,差异无统计学意义(P>0.05)。结论奥曲肽联合埃索美拉唑较单纯埃索美拉唑更能有效降低十二指肠溃疡合并出血患者的出血率、再出血率,且不会增加不良反应。Objective To investigate the influences of octreotide combined with esomeprazole in average bleeding rate,rebleeding rate and adverse reaction of patients with bleeding duodenal ulcer.Methods 80 cases of patients with duodenal ulcer bleeding in our hospital from May 2014 to May 2016 were selected,they were randomly divided into simple esomeprazole treatment group（alone treatment group）and octreotide plus esomeprazole treatment group（combined treatment group）,the clinical efficacy,average bleeding,rebleeding,average hemostasis time,incidences of adverse reactions of the two groups were statistically analyzed.Results The total treatment efficiency of the combined treatment group 97.5% was higher than alone treatment group 80.0%,the difference was statistically significant（P〈0.05）;the bleeding rate,rebleeding rate 5.0% and 0 were lower than the alone treatment group 15.0%and 5.0%,the difference was statistically significant（P〈0.05）;the average bleeding time was shorter than the alone treatment group,the difference was statistically significant（P〈0.05）;the incidences of adverse reactions between the two groups were10.0% and 10.0%,the difference was not statistically significant（P〉0.05）.Conclusion Octreotide combined with esomeprazole can more effectively reduce the bleeding rate,rebleeding rate,without increasing the adverse reactions of patients with duodenal ulcer bleeding than simple esomeprazole.

关 键 词：奥曲肽联合埃索美拉唑 十二指肠溃疡合并出血 平均出血率 再出血率 不良反应 

分 类 号：R573.105[医药卫生—消化系统]