PET/CT与MRI/CT在鼻咽癌原发灶靶区勾画中的可行性研究  

Comparative study of gross tumor volume shown on FDG PET/CT and MRI/CT of nasopharyngealcarcinoma

作　　者：周育夫[1] 张亚军[1] 孙谦[1] 汪庚明[1] 徐洪波[1] 周燕[1] 李多杰[1] 刘静景[1] 沈学明[1] 江浩[1] 

机构地区：[1]蚌埠医学院第一附属医院肿瘤放疗科,安徽蚌埠233004

出　　处：《安徽医学》2017年第7期837-840,共4页Anhui Medical Journal

基　　金：蚌埠医学院第一附属医院高新技术准入项目(项目编号:201444)

摘　　要：目的对比PET/CT不同阈值勾画方法及MRI/CT融合图像勾画方法示鼻咽癌肿瘤体积的差异,探讨PET/CT勾画鼻咽癌肿瘤靶区(GTV_()最佳方法。方法选择2012年1月至2014年1月蚌埠医学院第一附属医院50例病理组织学确诊为鼻咽癌的患者入组。在MRI/CT融合图像上勾画获得GTV_(MRI/CT),在PET/CT融合图像上以SUV值为2.5自动勾画得到GTV_(PET2.5),以40%最大标准摄取值自动勾画得到GTV_(PET40%,以50%最大标准摄取值自动勾画得到GTV_(PET50%。线性回归分析各体积之间相关性。结果 GTV_(MRI/CT),GTV_(PET2.5),GTV_(PET40%),GTV_(PET50%)分别为(23.50±15.44)cm^3,(30.72±17.72)cm^3,(23.41±15.08)cm^3,(19.12±13.26)cm^3。GTV_(PET2.5)大于GTV_(PET40%)和GTV_(MRI/CT(P<0.05)),GTV_(PET40%)大于GTV_(PET50%(P<0.05)),GTV_(PET50%小于GTV_(MRI/CT(P<0.05),GTV_(PET40%与GTV_(MRI/CT相比差异无统计学意义(P>0.05)。GTV_(MRI/CT与GTV_(PET2.5)、GTV_(PET40%)、GTV_(PET50%)密切相关(r=0.978、0.991、0.990,P<0.05)。结论采用40%最大标准摄取值自动勾画肿瘤靶区是临床较佳选择。Objective To compare the primary tumor volume measured by FDG PET and MRI/CT in nasopharyngeal carcinoma and determine the optimal method for target volume delineation of nasopharyngeal carcinoma. Methods From Jan. 2012 to Jan. 2014,50 patients with pathological diagnosed NPC were enrolled. The primary tumor volumes derived from the four methods,GTV_(MRI/CT,GTV_(PET2. 5)( autocontouring with the threshold of SUV≥2. 5),GTV_(PET40%)( autocontouring with the threshold of≥40% of SUVmax),GTV_(PET50%)( autocontouring with the threshold of≥40% of SUVmax) were compared with paired t test. Linear regression analysis was used to analyze the correlation coefficients between the MRI/CT and PET-derived tumor volumes. Results GTV_(MRI/CT,GTV_(PET2. 5,GTV_(PET40%),GTV_(PET50%)was 23. 50 ± 15.44cm^3,30. 72 ± 17. 72cm^3,23. 41 ± 15. 08cm^3,19. 12 ± 13. 26cm^3,respectively. GTV_(PET2. 5)was significantly larger than GTV_(PET40%)and GTV_(MRI/CT)( P < 0. 05),GTV_(PET40%)was significantly larger than GTV_(PET50%)( P < 0. 05),GTV_(PET50%)was significantly smaller than GTV_(MRI/CT)( P< 0. 05),and no significant difference was noted between GTV_(MRI/CT)and GTV_(PET40%)( P > 0. 05). The correlation of GTV_(MRI/CT)and GTV_(PET2. 5),GTV_(PET40%),GTV_(PET50%)was good( r = 0. 978,0. 991,0. 990,P < 0. 05). Conclusion The threshold of≥40% of SUVmax can be used for target volume delineation of nasopharyngeal carcinoma.

关 键 词：鼻咽癌 肿瘤体积 正电子发射断层显像术 计算机断层显像术 磁共振成像 勾画 

分 类 号：R739.63[医药卫生—肿瘤]