人类精子染色体非整倍体研究进展  

Research progress on aneuploid of human sperm chromosome

作　　者：彭向杰 黄川 范立青 卢光琇 朱文兵 PENG Xiang-jie;HUANG Chuan;FAN Li-qing;LU Guang-xiu;ZHU Wen-bing(Reproductive ＆ Genetic Hospital of CITIC-XiangYa ,Changsha 410000;Institute of Reproductive ＆ Stern Cell Engineering, Basic Medicine College, Central South University, Changsha 410000)

机构地区：[1]中信湘雅生殖与遗传专科医院,长沙410000 [2]中南大学基础医学院生殖与干细胞工程研究所,长沙410000

出　　处：《生殖医学杂志》2017年第11期1109-1113,共5页Journal of Reproductive Medicine

基　　金：湖南省重点研发计划项目(2016WK2019)

摘　　要：人类最常见的染色体异常是非整倍体。由于在胚胎发育的早期阶段多数的非整倍体胚胎会停止发育,因此对胚胎的非整倍体率的精确评估多通过对配子的直接研究来进行。大多数非整倍体胚胎的产生,是由于父源或母源性减数分裂中偶然的染色体不分离所导致。本文综述了正常人群的精子非整倍体发生率以及不同种类患者的精子非整倍体率,包括不育患者、体细胞核型异常患者,以及暴露于某些有害的环境或生活方式中的个体;并对精子非整倍体率升高的临床影响进行讨论。The most common chromosomal abnormality in human is aneuploidy.Since the majority of aneuploid embryos cease to develop during the early stages of embryonic development,accurate estimate of aneuploid rate in embryos is mostly carried out by direct studies of gametes.The most of aneuploid embryos are caused by accidental chromosomes non-disjunction in the paternal or maternally derived meiosis.This paper reviews the sperm aneuploid rate in normal men and different types of patients with infertility or somatic chromosome abnormalities,as well as the individuals exposed to harmful environment or lifestyle.The clinical impacts of higher sperm aneuploid rate are also discussed.

关 键 词：非整倍体 减数分裂 染色体不分离 精子 

分 类 号：R[医药卫生]