兰索拉唑联合文拉法辛心身同治难治性消化性溃疡的临床疗效观察  

Clinical effect of lansoprazole combined venlafaxine and psychosomatic treatment on intractable peptic ulcer

作　　者：申妮[1] 张永利 薛顺和 乔丽娜 

机构地区：[1]延安大学附属医院消化内科,陕西延安716000 [2]铜川市人民医院(南院)内三科,陕西铜川727100 [3]延安市中医医院急诊科,陕西延安716000

出　　处：《西部医学》2017年第11期1537-1539,1546,共4页Medical Journal of West China

基　　金：陕西省自然科学基础研究重点项目(2014JZ154)

摘　　要：目的观察兰索拉唑联合文拉法辛心身同治难治性消化性溃疡的临床疗效。方法选取难治性消化性溃疡患者120例,按照随机抽签法分为对照组和观察组各60例。对照组患者实施兰索拉唑联合赛乐特治疗,观察组患者实施兰索拉唑联合文拉法辛心身同治。观察两组患者的临床疗效、心理状态和不良反应发生率并进行分析比较。结果观察组和对照组患者的临床治疗有效率分别为96.67%和81.67%,两组间差异有统计学意义(P<0.05)。观察组患者的焦虑、抑郁评分与治疗前比较,差异有统计学意义(P<0.05);治疗后观察组与对照组患者的焦虑、抑郁评分比较,差异有统计学意义(P<0.05)。观察组与对照组患者治疗中的不良反应发生率分别为5.00%和20.00%,差异有统计学意义(P<0.05)。结论在难治性消化性溃疡患者治疗的过程中,对其实施兰索拉唑联合文拉法辛心身同治,可以有效提高患者的临床治疗效果,改善患者的心理状态,提高患者治疗的依从性,降低不良反应的发生率,疗效显著。Objective To study the clinical effect of lansoprazole combined venlafaxine and psychosomatic treatment on intractable peptic.Methods 120 patients with intractable peptic ulcer were selected and randomly divided into the control group and the observation group with 60 cases in each group.Control group was treated with lansoprazole combined venlafaxine.Observation group was treated with lansoprazole combined venlafaxine and psychosomatic treatment.The clinical therapeutic effects,psychological state and incidence of adverse reactions were analyzed.Results The clinical treatment effect of observation group and control group were 96.67%and 81.67%（P〈0.05）.The anxiety and depression scores of observation group after treatment was statistically different from that before treatment（P〈0.05）.The anxiety and depression scores of observation group after treatment was lower than that of control group（P〈0.05）.The incidence of adverse reactions of observation group and control group were 5.00% and 20.00%（P〈0.05）.Conclusion Lansoprazole combined venlafaxine and psychosomatic treatment on intractable peptic ulcer can effectively improve the clinical treatment effect,the patient＇s mental state,the patients compliance and reduce the occurrence of adverse reactions.

关 键 词：兰索拉唑 文拉法辛 心身同治 难治性消化性溃疡 

分 类 号：R573.1[医药卫生—消化系统]