αβ-晶状体蛋白在肿瘤中的研究进展  

Advances in research on αβ-crystallin in malignancies

作　　者：吴永娜[1,2,3,4] 任程晖[1,3,4] 张磊 李汛 Wu Yong-na Ren Cheng-hui Zhang Lei Li Xun(Gansu Province Key Laboratory of Biotherapy and Regenerative Medicine, Lanzhou University, Lanzhou 730000, China Central Laboratory, Donggang Branch of First Hospital of L~inzhou University, Lanzhou 730020, China First School of Clinical Medicine, Lanzhou University, Lanzhou 730000, China Second Department of General Surgery, First Hospital of Lanzhou University, Lanzhou 730000, China)

机构地区：[1]兰州大学甘肃省生物治疗与再生医学重点实验室,甘肃兰州730000 [2]兰州大学第一医院东岗院区实验中心,甘肃兰州730020 [3]兰州大学第一临床医学院,甘肃兰州730000 [4]兰州大学第一医院普外二科,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2017年第5期68-72,共5页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金面上项目(31270543);甘肃卫生行业科研计划管理项目(GWGL2014-57)

摘　　要：αβ-晶状体蛋白(Cryab)是热休克蛋白家族中最重要的基因之一。Cryab在体内广泛表达,具有独特的生物学特性,主要作为分子伴侣参与蛋白质的合成、折叠、积聚、装配、运输和降解。最新研究证实Cryab在肿瘤中高表达,可作为癌基因在恶性肿瘤发生、发展中发挥重要作用。与肿瘤患者的预后有着密切关系,预示其存在潜在的应用价值。本文就Cryab基因的结构和功能,及其在恶性肿瘤中的研究进展和作用机制做一综述,以期为深入研究Cryab在肿瘤中的功能提供科学依据。Heat shock proteins are a group of highly conserved peptide protein, αβ-crystallin （Cryab） has become the most important gene of heat shock protein family. As the oncogenes, Cryab was highly expressed in tumors and played an important role. Cryab has a unique biological characteristics involved in complex physiological functions in vivo activity, as a molecular chaperone it involved in protein synthesis, foiding, accumulation, assembly, transport and degradation, and it is related with the prognosis of cancer patients, all these suggesting its potential application. In this paper, we reviewed the structure and function of Cryab gene and its research progress and mechanism in malignant tumor, so as to provide a scientific basis for further study of its function in tumor.

关 键 词：αβ-晶状体蛋白 肿瘤 机制 

分 类 号：R453.9[医药卫生—治疗学]