晚期上皮性卵巢癌手术评估模型的系统评价  

A Systematic Review of Surgical Evaluation Model for Advanced Epithelial Ovarian Cancer

作　　者：刘传忠[1] 李力[1] 赵冰冰[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科、区域性高发肿瘤早期防治研究教育部重点室验室,南宁530021

出　　处：《国际妇产科学杂志》2017年第5期524-528,共5页Journal of International Obstetrics and Gynecology

基　　金：广西科学研究与技术开发计划项目(桂科攻1140003A-33,桂科攻1140003A-34)

摘　　要：目的:系统评价晚期上皮性卵巢癌手术评估模型的准确性。方法:搜索Pubmed、Medline、Cochrane Library、Embase及CNKI、重庆维普、中国生物医学文献数据库中关于晚期上皮性卵巢癌理想肿瘤细胞减灭术评估模型的文献,对纳入文献的参考文献进行手工检索。检索语种限于英文和中文,检索时限均从建库截至2017年3月31日。对符合纳入标准的相关研究进行质量评价及数据提取,进行Meta分析。结果:共纳入11项相关研究。Meta分析结果显示:腹腔镜、CT和CA125评估模型总的敏感度及特异度分别为0.938、0.816、0.616及0.651、0.830、0.824。通过计算总受试者工作特征曲线(SROC)下面积计算相应模型的总准确度,腹腔镜、CT和CA125评估模型的AUC分别为0.949、0.928及0.828。结论:在所研究晚期卵巢癌接受理想肿瘤细胞减灭术的评估模型中,以CA125评估模型的准确性较差,CT及腹腔镜探查的评估模型均有着较高的准确性,其中腹腔镜评估的准确性最高。期待更多的大样本前瞻性临床试验对本研究结果进行验证。Objective：To evaluate the accuracy of the evaluation models for advanced epithelial ovarian cancer（AEOC）.Methods：Databases such as Pubmed,Cochrane Library,Medline,Embase and CNKI,VIP and CBM date were searched.Related literatures were published from the date of their establishment to March,31,2017.Reference articles of related articles were also researched.The searching language included Chinese and English.Meta-analysis was performed on studies meeting the inclusion criteria.Results：A total of 11 related studies were included.Meta-analysis showed that the total sensitivity and specificity of laparoscopy,CT and CA125 were 0.938,0.816,0.616 and 0.651,0.830,0.824 respectively.The total AUC of the corresponding model was calculated by calculating the area under the SROC curve.The AUC of the laparoscopy,CT and CA125 evaluation models were 0.949,0.928 and 0.828,respectively.Conclusions：In all evaluation models,the CA125 evaluation model shows poor accuracy,while the CT evaluation model and the laparoscopic exploration evaluation model have higher accuracy,and the accuracy of laparoscopic exploration evaluation model is the highest.We expect more larger sample prospective clinical trials to validate the results of our study.

关 键 词：卵巢肿瘤 治疗结果 META分析 晚期上皮性卵巢癌 理想肿瘤细胞减灭术 评估模型 

分 类 号：R737.31[医药卫生—肿瘤]