不同海拔地区汉族与藏族人群缺血性脑血管病患者血浆促动脉硬化指数(AIP)的对比研究  

Different levels of Han and Tibetan populations in patients with ischemic cerebrovascular disease A comparative study of plasma atherosclerotic index(AIP)

作　　者：郑建文 王宇鹤[2] 董鸿志 徐世林[2] 赵锋仓[1] 莫芳萍[1] ZHENG Jian-wen WANG Yu-he DONG Hong-zhi XU Shi-lin ZHAO Feng-cang MO Fang-ping(Afliated hospital of the Tibet university of nationalities,1.Department of cardiovascular and cerebrovascular diseases,2.clinical laboratory Shaanxi Xianyang 712082,China)

机构地区：[1]西藏民族大学附属医院心脑血管内科,陕西咸阳712082 [2]西藏民族大学附属医院检验科,陕西咸阳712082

出　　处：《中西医结合心血管病电子杂志》2017年第16期95-97,共3页Cardiovascular Disease Electronic Journal of Integrated Traditional Chinese and Western Medicine

基　　金：西藏自治区科技厅项目(No:2015ZR-13-14)

摘　　要：目的探讨在不同海拔地区汉族和藏族缺血性脑血管病患者血浆促动脉硬化指数(AIP)的水平变化及对比。方法前瞻性纳入不同海拔地区确诊为缺血性脑血管病患者308例,其中汉族203例、藏族105例,203例汉族患者中高海拔地区(2200 m以上)104例,低海拔地区(450 m以下)99例。并选择与汉族患者年龄、地区、性别基本相似的汉族健康体检者作为对照组,高海拔与低海拔地区的对照组体检者分别有87名或101名。所入选的藏族患者105例均来自高海拔地区,选取同地区、性别、年龄等基础资料基本相符的藏族健康体检者109名作为对照组。所选入的所有患者与健康体检者均进行总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等血浆脂质代谢水平的检测,计算出血浆促动脉硬化指数(AIP),并进行对比分析。结果 (1)高、低海拔地区汉族缺血性脑血管病患者AIP(0.171±0.078)、(0.111±0.082)均高于相应健康对照组(-0.025±0.041),差异均有统计学意义(P<0.001)。(2)汉族患者组与健康对照组AIP高海拔区均高于低海拔区,患者组更明显,差异有统计学意义(P<0.001),健康对照组差异不明显,无统计学意义。(3)高海拔区藏族患者组AIP明显高于健康对照组,差异有显著意义(P<0.001)。(4)高海拔区藏族健康组AIP与汉族健康组比较,没有差异,无统计学意义(P>0.05)。结论随着海拔的增高,汉族缺血性脑血管病患者与健康对照组AIP均升高,缺血性脑血管病患者升高更明显。在高海拔区藏族患者AIP明显高于汉族患者,但健康对照组无差异。Objective To investigate the changes and contrast of plasma atherosclerotic index （AIP） in patients with ischemic cerebrovascular disease in Han and Tibetan areas at di？erent altitudes.Methods There were 308 patients with ischemic cerebrovascular disease diagnosed at different altitudes,including 203 Han patients,105 cases of Tibetan nationality,104 cases of high-altitude area（20300 mm）,203 cases of low-altitude area（450m or less）example.And choose the Han nationality patients with age,region,gender similar to the health of the Han as a control group,high altitude and low altitude areas of the control group were 87 or 101. 105 cases of Tibetan patients were selected from the high altitude areas, selected with the region, gender,age and other basic data basically consistent with the Tibetan health examination of 109 as the control group. Plasma levels of total cholesterol （TC）,triglyceride （TG）,low density lipoprotein （LDL-C）,high density lipoprotein （HDL-C）and other plasma lipid levels were measured in all selected patients and healthy subjects （AIP）, and the comparative analysis was performed.Results （1）AIP（0.171±0.078）and（0.111±0.082）in patients with ischemic cerebrovascular disease were higher than those in the corresponding healthy control group（-0.025±0.041）,the difference was statistically significant（P〈0.001）.（2）There was significant difference between the Han group and the healthy control group （P〈0.001）,but there was no significant difference between the healthy control group and the healthy control group Statistical significance.（3）The AIP of the Tibetan group was significantly higher than that of the healthy control group （P〈0.001）.（4）There was no significant difference between group AIP and Han nationality health group（P〉0.05）.Conclusion With the increase of altitude,the level of AIP in patients with ischemic cerebrovascular disease and healthy control group increased,and the number of patients with ischemic c

关 键 词：高海拔地区 低海拔地区 汉族与藏族 缺血性脑血管病 血浆致动脉硬化指数 

分 类 号：R743.1[医药卫生—神经病学与精神病学]