脑胶质瘤的外科手术近代观点  

Up-to-date viewpoint of cerebral glioma surgery

作　　者：吴劲松[1,2] 周良辅 

机构地区：[1]复旦大学神经外科研究所,上海200040 [2]复旦大学附属华山医院神经外科脑胶质瘤中心,上海200040

出　　处：《复旦学报（医学版）》2017年第6期724-732,共9页Fudan University Journal of Medical Sciences

基　　金："十二五"国家科技支撑计划(2014BAI04B05)

摘　　要：当今,脑胶质瘤手术的首要目标是:争取最大程度和安全切除,减少肿瘤细胞负荷,保障患者生活质量,为术后放疗、化疗(靶向治疗)以及免疫治疗等个体化综合治疗创造最优条件。综合运用神经导航、iMRI术中实时影像导航、多模态影像导航、术中荧光显像技术、唤醒麻醉以及术中电生理监测等新技术,实现多模态脑功能精确定位和保护及脑肿瘤定量切除,不仅可达到脑胶质瘤手术的目标,而且有助我国脑计划研究的实现。Today,the primary goal of cerebral glioma surgery is to achieve maximum safe resection. The cytoreductive surgery ensures the sensitivity to postoperative radiotherapy, chemotherapy （targeted therapy） and immunotherapy and other individualized adjuvant treatment, while limits sacrifice of the quality of life of patients. Comprehensive use of neuronavigation, iMRI intraoperative real-time image guidance, multimodal functional and metabolic image guidance,intraoperative fluorescence technology, awake craniotomy and intraoperative electrophysiological monitoring and other new technologies to achieve accurate positioning of multi-mode brain function, real-time protection and quantitative control of extent of tumor resection,are not only achieving the promising goal of cerebral glioma surgeries, but enhancing the realization of the China Brain Project.

关 键 词：外科手术 脑胶质瘤 近代观点 细胞负荷 生活质量 全切除 

分 类 号：R739.41[医药卫生—肿瘤]