SIRT3通过线粒体途径调控年龄相关疾病——从发病机制到治疗  

SIRT3 Regulates Age-Related Diseases via Mitochondrial Pathway: From Pathogenesis to Therapy

作　　者：王建乐 张小磊 王向阳[1,2] 

机构地区：[1]温州医科大学附属第二医院育英儿童医院骨科,温州325027 [2]浙江省骨科学重点实验室,温州325027

出　　处：《中国细胞生物学学报》2017年第10期1349-1356,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81371988);浙江省医药卫生重大科技计划(批准号:WKJ-ZJ-1527);浙江省自然科学基金(批准号:LY17H060010)资助的课题~~

摘　　要：细胞中损伤线粒体出现堆积现象是年龄相关疾病的特征之一。当细胞受到氧化应激时,作为一种NAD+依赖性的去乙酰基酶—SIRT3可以通过调节线粒体功能与代谢来对抗外界刺激。SIRT3作用于线粒体的机制较复杂,包括了能量的产生、抗氧化、线粒体动力学变化、维持膜电位以及线粒体自噬等。作为研究热点,SIRT3正被学者们从各个方面进行探索。然而,目前现有关于SIRT3与年龄相关疾病的系统性总结。因此,该文将从发病机制到治疗对SIRT3和年龄相关疾病作一综述。One of the common features of age-related diseases is progressive accumulation of defective mitochondria. As a NAD＋-dependent protein deacetylase, SIRT3 regulates mitochondrial function and metabolism in response to oxdiative stress. The effects of SIRT3 on mitochondria are complicated, including energy production, antioxidation, mitochondrial dynamics, sustaining membrane potential and mitophagy, etc. SIRT3 has been explored from different aspects. However, there are still few summaries that systematacially illuminate how SIRT3 exerts its functions in protecting organism against age-related diseases. Thus, the aim of this review is to elucidate the relationship between SIRT3 and age-related diseases from pathogenesis to therapy.

关 键 词：SIRT3 年龄相关疾病 线粒体 治疗 

分 类 号：R363[医药卫生—病理学]