Chemoselective Synthesis of Novel Heterocyclic [3.3.3]Pro- pellane Derivatives via a One-pot Three-component Reaction  

作　　者：Jing Wang Hongzhi Liu Ren Wen Jie Li Songlei Zhu 

机构地区：[1]Department of Chemistry, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China [2]Zhengda Tianqing Pharmaceutical Group Co., LTD, Lianyungang, Jiangsu 222062, China

出　　处：《Chinese Journal of Chemistry》2017年第9期1463-1468,共6页中国化学（英文版）

摘　　要：A highly chemoselective method for the synthesis of heterocyclic [3.3.3]propellane derivatives was developed via sequential three-component reactions of acenaphthenequinone, malononitrile/cyanoacetate and a variety of 1,3-dicarbonyl compounds under mild conditions in ethanol. A plausible mechanism for this type of reaction was proposed. The value of this method was highlighted by its high selectivity, simple procedures, and good yields.A highly chemoselective method for the synthesis of heterocyclic [3.3.3]propellane derivatives was developed via sequential three-component reactions of acenaphthenequinone, malononitrile/cyanoacetate and a variety of 1,3-dicarbonyl compounds under mild conditions in ethanol. A plausible mechanism for this type of reaction was proposed. The value of this method was highlighted by its high selectivity, simple procedures, and good yields.

关 键 词：ACENAPHTHENEQUINONE oxa-aza[3.3.3]propellane CHEMOSELECTIVITY multi-component reaction 

分 类 号：TQ925[轻工技术与工程—发酵工程] TQ463.25