Emerging role of HuR in inflammatory response in kidney diseases  

作　　者：Jin Shang Zhanzheng Zhao 

机构地区：[1]Nephrology Hospital, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

出　　处：《Acta Biochimica et Biophysica Sinica》2017年第9期753-763,共11页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China （No. 81570690） and Excellent Youth Foundation of Henan Scientific Committee （No. 292154100510017）.

摘　　要：Human antigen R （HuR） is a member of the embryonic lethal abnormal vision （ELAV） family which can bind to the A/U rich elements in 3＇ un-translated region of mRNA and regulate mRNA splicing, transportation, and stability. Unlike other members of the ELAV family, HuR is ubiquitously expressed. Early studies mainly focused on HuR function in malignant diseases. As researches proceed, more and more proofs demonstrate its relationship with inflammation. Since most kid- ney diseases involve pathological changes of inflammation, HuR is now suggested to play a piv- otal role in glomerular nephropathy, tubular ischemia-reperfusion damage, renal fibrosis and even renal tumors. By regulating the mRNAs of target genes, HuR is causally linked to the onset and progression of kidney diseases. Reports on this topic are steadily increasing, however, the detailed function and mechanism of action of HuR are still not well understood. The aim of this review article is to summarize the present understanding of the role of HuR in inflammation in kidney diseases, and we anticipate that future research will ultimately elucidate the therapeutic value of this novel target.Human antigen R （HuR） is a member of the embryonic lethal abnormal vision （ELAV） family which can bind to the A/U rich elements in 3＇ un-translated region of mRNA and regulate mRNA splicing, transportation, and stability. Unlike other members of the ELAV family, HuR is ubiquitously expressed. Early studies mainly focused on HuR function in malignant diseases. As researches proceed, more and more proofs demonstrate its relationship with inflammation. Since most kid- ney diseases involve pathological changes of inflammation, HuR is now suggested to play a piv- otal role in glomerular nephropathy, tubular ischemia-reperfusion damage, renal fibrosis and even renal tumors. By regulating the mRNAs of target genes, HuR is causally linked to the onset and progression of kidney diseases. Reports on this topic are steadily increasing, however, the detailed function and mechanism of action of HuR are still not well understood. The aim of this review article is to summarize the present understanding of the role of HuR in inflammation in kidney diseases, and we anticipate that future research will ultimately elucidate the therapeutic value of this novel target.

关 键 词：ELAV-Like protein 1 mRNA stability INFLAMMATION kidney diseases 

分 类 号：S858.31[农业科学—临床兽医学] Q555.7[农业科学—兽医学]