前炎性细胞因子在抑郁症中的作用  

Role of Preinflammatory Cytokines in Depression

作　　者：杨英杰 刘茂航 游芳馨 邱继红[1] 

机构地区：[1]重庆市精神卫生中心医务科,重庆400147 [2]重庆市江北区疾病预防控制中心慢病免疫科,重庆400010

出　　处：《医学综述》2017年第22期4393-4396,共4页Medical Recapitulate

摘　　要：前炎性细胞因子如白细胞介素1、白细胞介素6、γ干扰素和肿瘤坏死因子α等在抑郁症中多表达增加,过度表达的前炎性细胞因子与中枢5-羟色胺损耗、下丘脑-垂体-肾上腺轴的功能失调有关,促进神经细胞死亡,导致快感缺失;前炎性细胞因子间还可协同作用加重损害中枢神经系统。抗抑郁药物可降低前炎性细胞因子水平,抗炎治疗亦可改善抑郁,以抗炎药物为先导化合物的新药在抑郁症的治疗中有重要的应用前景。Excessive expression of preinflammatory cytokines such as interleukin-1 and interleukin-6,interferon-γ and tumor necrosis factor-or has been connected to depletion of serotonin in central nervous system and dysfunction of hypothala- mus-pituitary-adrenal axis in depressive patients, resulting in death of the neuronal cells and anhedonia; preinflammatory cytokines also have a synergistic effect on damage of central nervous system. Fortunately, antidepressants can reduce the level of preinflammatory cytokines, and anti-inflammatory therapy can ameliorate depression, new antidepressants combined anti-inflammatory drugs may have an important application in the treatment of depression.

关 键 词：抑郁症 细胞因子 前炎性细胞因子 抗抑郁药 

分 类 号：R749[医药卫生—神经病学与精神病学]