UHRF1蛋白在乳腺癌组织中的表达及其与局部复发的相关性  

Expression of UHRF1 protein in breast cancer tissue and its correlation with local recurrence

作　　者：耿冲[1] 张旭光[1] 叶涛[1] 惠华[1] 王强[1] 王敏[1] 孙苏平[1] 李新莉[2] 

机构地区：[1]江苏省徐州市肿瘤医院放疗二科,221005 [2]苏州大学放射医学与防护学院,215123

出　　处：《肿瘤研究与临床》2017年第10期670-672,共3页Cancer Research and Clinic

基　　金：江苏省卫生和计划生育委员会指导性科研项目（Z201224）

摘　　要：目的 分析UHRF1蛋白在乳腺癌组织及癌旁正常组织中的表达及其与局部复发的相关性.方法 采用免疫组织化学方法 检测69例乳腺癌组织及33例癌旁正常组织中UHRF1蛋白的表达.采用χ2检验分析UHRF1蛋白表达与患者临床特征之间的关系.结果 UHRF1蛋白在乳腺癌组织中的阳性表达率为55.1%（38/69）,癌旁正常乳腺组织中未见UHRF1蛋白表达.UHRF1蛋白在Ⅲ期患者中的阳性表达率高于Ⅰ~Ⅱ期患者[68.4%（26/38）比38.7%（12/31）,P〈0.05],在放疗后1年胸壁复发患者中阳性表达率高于未复发患者[83.3%（10/12）比49.1%（28/57）,P〈0.05],而不同年龄及不同Herb-2表达状态患者间UHRF1蛋白阳性表达率比较,差异均无统计学意义（均P〉0.05）.结论 UHRF1蛋白在乳腺癌组织中的阳性表达率高于癌旁正常组织,其与分期及放疗后胸壁的局部复发相关.Objective To investigate the expression of UHRF1 protein in breast cancer and adjacent normal tissues, and its relationship with local recurrence. Methods Immunohistochemistry （IHC） was applied to detect the expression of UHRF1 protein in 69 specimens of breast cancer and 33 specimens of corresponding adjacent normal tissues; Chi-square test was used to analyze the relationship between UHRF1 protein expression and clinical factors. Results The positive rate expression of UHRF1 protein in breast cancer was 55.1 % （38/69）, and UHRF1 protein expression was not found in adjacent normal tissues. The positive expression rate of UHRF1 protein in stage III was higher than that in stageⅠ-Ⅱ[68.4%（26/38） vs. 38.7 % （12/31）, P〈 0.05]. The positive expression rate of cancer tissue in breast cancer patients with chest wall recurrence after radiotherapy within 1 year was higher than that in patients without recurrence [83.3 %（10/12） vs. 49.1 % （28/57）, P〈 0.05], and UHRF1 protein expression of patients in different age and Herb-2 had no statistical significance （P〉 0.05）. Conclusions The positive expression rate of UHRF1 protein is obviously higher than that in adjacent normal tissue. Besides, UHRF1 protein is related to the stage and chest wall of local recurrence after radiotherapy.

关 键 词：乳腺肿瘤 辐射耐受性 UHRF1蛋白 

分 类 号：R737.9[医药卫生—肿瘤]