乳腺癌患者血清转铁蛋白受体和血管紧张素Ⅱ水平的变化及其临床意义  

Change of Serum Transferrin Receptor( STFR) and Angiotensin Ⅱ(AT Ⅱ) Levels in Breast Cancer Patients and Its Clinical Significance

作　　者：翟勇 于士昌[2] 李永涛[2] 

机构地区：[1]河北省唐山市曹妃甸区医院,063200 [2]解放军第260医院,050000

出　　处：《实用癌症杂志》2017年第1期19-20,29,共3页The Practical Journal of Cancer

摘　　要：目的探讨乳腺癌(BC)患者血清转铁蛋白受体(STFR)和血管紧张素Ⅱ(ATⅡ)水平的变化及其临床意义。方法随机选取50例BC患者作为BC组,50例同期健康查体妇女为健康组。检测2组血清转铁蛋白受体和血管紧张素Ⅱ水平变化,并分析其与5年生存率(5YSR)的关系。结果 BC组治疗前后的血清转铁蛋白受体和血管紧张素Ⅱ均高于健康组(P<0.05);与治疗前比较,BC组治疗后的血清转铁蛋白受体和血管紧张素Ⅱ均降低(P<0.05)。存活患者血清转铁蛋白受体和血管紧张素Ⅱ水平均低于死亡患者(P<0.05)。血清转铁蛋白受体及血管紧张素Ⅱ与5年生存率均呈负相关(γ=-0.756,-0.732,P<0.05)。结论 BC患者血清转铁蛋白受体及血管紧张素Ⅱ水平较高且与预后相关,可能作为BC诊断及预后评估的参考指标。Objective To investigate the change of serum transferrin receptor and angiotensin Ⅱlevels in breast cancer patients and its clinical significance.Methods 50 cases of breast cancer as BC group and 50 cases of health people as health group.Test the serum transferrin receptor and angiotensin Ⅱlevel of the 2 groups,and the relation with 5-year survival rate ana-lyzed.Results Both the serum transferrin receptor and angiotensin Ⅱlevel in BC group were higher the health group before and after treatment（P〈0.05）.After treatment,the serum transferrin receptor and angiotensin Ⅱ level in BC group were lower than before treatment（P〈0.05）.The serum transferrin receptor and angiotensin Ⅱ levels in survival patients were lower than death patients（P〈0.05） and negatively correlated with 5-year survival rate（γ=-0.756,-0.732,P〈0.05）.Conclusion Serum transferrin receptor and angiotensin Ⅱin BC patients are higher than health people and associate with BC determination and prog -nosis evaluation as the important reference index.

关 键 词：乳腺癌 血清转铁蛋白受体 血管紧张素Ⅱ 

分 类 号：R737.9[医药卫生—肿瘤]