老年急性脑梗死患者血清CysC和hs-CRP的变化及临床意义  

Changes of serum CysC and hs-CRP levels and their clinical significances in elderly patients with acute cerebral infarction

作　　者：彭细娟 姚立农[1] 董敬之 吴巍[1] 罗涛[2] 

机构地区：[1]第四军医大学唐都医院重症监护室,陕西西安710038 [2]第四军医大学唐都医院神经外科重症监护室,陕西西安710038

出　　处：《临床医学研究与实践》2017年第17期1-3,共3页Clinical Research and Practice

基　　金：国家自然科学基金(No.30872444)

摘　　要：目的研究老年急性脑梗死患者血清胱抑素C(Cys C)和超敏C反应蛋白(hs-CRP)的变化及临床意义。方法前瞻性收集首次入我院治疗的急性脑梗死老年患者78例作为观察组和同期30例健康体检者作为对照组,检测两组受检者的血清Cys C和hs-CRP浓度,同时记录观察组患者入院时和治疗后3个月的NIHSS评分并分析其与血清Cys C和hs-CRP水平的关系。结果入院时,观察组患者的Cys C和hs-CRP水平均高于对照组(P<0.05);治疗后1周,观察组患者的Cys C和hs-CRP水平随着相关治疗逐渐降低,均低于治疗前,但仍高于对照组(P<0.05);治疗后3个月,观察组患者的Cys C和hs-CRP水平明显低于治疗前(P<0.01),但Cys C水平与对照组比较,差异无统计学差异(P>0.05),hs-CRP水平仍然高于对照组(P<0.01)。观察组患者的入院时的Cys C、hs-CRP水平与脑梗死体积呈正相关关系(P<0.01)。观察组患者入院时的Cys C、hs-CRP水平与NIHSS评分呈正相关(P<0.01);Cys C、hs-CRP水平与治疗3个月后的NIHSS评分也呈正相关(P<0.01)。结论急性脑梗死老年患者血清Cys C和hs-CRP水平升高,其升高程度与病情严重程度密切相关,测定这两项指标有助于预测患者治疗3个月后的病情转归情况。Objective To investigate the changes and clinical significances of serum Cystatin C（Cys C） and high sensitivity C-reactive protein（hs-CRP） in elderly patients with acute cerebral infarction. Methods Seventy-eight cases of elderly patients with acute cerebral infarction in our hospital were prospectively selected as the observation group, and 30 cases of healthy subjects in the same period were selected as the control group. The levels of serum Cys C and hs-CRP in the two groups were measured, the NIHSS score was recorded at admission and 3 months after treatment and its relationships between serum Cys C and hs-CRP levels were also analyzed. Results At admission, the levels of Cys C and hs-CRP in the observation group were higher than those of the control group（P〈0.05）; After treatment for 1 week, the levels of Cys C and hs-CRP in the observation group decreased with the treatment conducted, and were lower than those before treatment, but were higher than those of the control group（P〈0.05）; After treatment for 3 months, the levels of Cys C and hs-CRP in the observation group were significantly lower than those before treatment（P〈0.01）, but there was no significant difference in the Cys C level between the two groups（P〉0.05）, and the hs-CRP level in the observation was still higher than that of the control group（P〈0.05）. At admission, there were positive relationships between the levels of Cys C, hc-CRP and the relative infarct volume（P〈0.01）; At admission, there were positive relationships between the levels of Cys C, hs-CRP and NIHSS scores（P〈0.01）; After treatment for 3 months, there were also positive relationships between the levels of Cys C,hs-CRP and NIHSS scores（P〈0.01）. Conclusion The levels of serum Cys C and hs-CRP in elderly patients with acute cerebral infarction increases, and the degree of elevation was closely related to the severity of the disease, the determination of the two indicators will help to predict the outcome of the patients＇ afte

关 键 词：急性脑梗死 胱抑素C 超敏C反应蛋白 

分 类 号：R743.33[医药卫生—神经病学与精神病学]