还原型谷胱甘肽联合介入治疗对原发性肝癌疗效及肝功能影响研究  

Study on the effect of reduced glutathione combined with interventional therapy on primary liver cancer and liver function

作　　者：楼建[1] 宋晶晶[2] LOU Jian;SONG Jingjing(DeparLmenL of Oncology, Lishui CenLral HospiLal in Zhejiang Province, Lishui 323000, China;DeparLment of In-vasive Technology, Lishui CenLral HospiLal in Zhejiang Province, Lishui 323000, China)

机构地区：[1]浙江省丽水市中心医院肿瘤内科,浙江丽水323000 [2]浙江省丽水市中心医院介入科,浙江丽水323000

出　　处：《中国现代医生》2017年第30期4-7,共4页China Modern Doctor

基　　金：浙江省科技计划项目(2013C03010)

摘　　要：目的探讨还原型谷胱甘肽联合介入治疗对原发性肝癌疗效及肝功能的影响。方法选取2014年6月~2017年3月我院肿瘤科收治的71例原发性肝癌患者,随机分为观察组(还原型谷胱甘肽联合介入治疗)36例、对照组(常规药物联合介入治疗)35例,比较两组肝功能指标及疗效。结果治疗前,两组谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBIL)水平比较差异无统计学意义(P>0.05);治疗后,观察组各项肝功能指标均优于对照组,差异具有统计学意义(P<0.05)。观察组治疗有效率为86.11%,明显高于对照组的62.86%,差异具有统计学意义(P<0.05)。结论还原型谷胱甘肽能改善原发性肝癌患者接受介入治疗引起的肝功能损伤,提高治疗的有效性及安全性,值得临床推广采用。Objective To investigate the effect of reduced glutathione combined with interventional therapy on primary liver cancer and liver function. Methods 71 patients with primary liver cancer who were admitted to the department of Oncology in our hospital from June 2014 to March 2017 were selected. They were randomly divided into 36 cases in the observation group（reduced glutathione combined with interventional therapy）, and 35 cases in the control group （conventional drugs combined with interventional therapy）. tiver function indices and efficacy were compared between the two groups. Results There were no statistically significant differences in the levels of AtT, AST, AtP and TBIt be-fore the treatment between the two groups（P〉0.05）; after the treatment, the liver function indices in the observation group were better than those in the control group, and the differences were statistically significant（P〈0.05）, the effective rate in the treatment group was 86.11%, which was significantly higher than that in the control group（62.86%）, the dif-ference was statistically significant（P〈0.05）. Conclusion Reduced glutathione can improve the liver injury induced by interventional therapy in the patients with primary liver cancer, and improve the efficacy and safety of treatment, which is worthy of clinical promotion and application.

关 键 词：还原型谷胱甘肽 介入治疗 原发性肝癌 肝功能 

分 类 号：R735.7[医药卫生—肿瘤]