丹参多酚酸盐联合奥拉西坦治疗高龄腔隙性脑梗死临床疗效观察  

Observation on clinical efficacy of salvianolate combined with oxiracetam in the treatment of aging lacunar cerebral infarction

作　　者：费明峰[1] 赵园园[1] 吴玉泉[1] 郦虹 许娟[1] 郑伟 FEI Mingfeng;ZHAO Yuanyuan;WU Yuquan;LI Hong;XU Juan;ZHENG Wei(Department of Cadre＇s Ward, the 117th Hospital of People＇s Liberation Army, Nanjing Military Region Geriatric Dis-ease Diagnosis and Treatment Center, Hangzhou 310013, China)

机构地区：[1]解放军第一一七医院干部病房南京军区老年病诊治中心

出　　处：《中国现代医生》2017年第30期11-14,共4页China Modern Doctor

基　　金：浙江省科技计划项目(2015C33179);浙江省杭州市卫生计生科技项目(2015B60)

摘　　要：目的观察丹参多酚酸盐联合奥拉西坦治疗高龄腔隙性脑梗死患者的疗效。方法选择2013年1月~2016年12月收治的年龄≥80岁的急性腔隙性脑梗死患者139例,随机分为两组,治疗组70例、对照组69例。在基础治疗上,治疗组应用丹参多酚酸盐联合奥拉西坦治疗,对照组单用奥拉西坦,14 d为1个疗程;观察两组患者治疗前后血栓前体蛋白及血液流变学指标改变、神经功能缺损程度评分、日常生活能力变化及认知功能评分的差异,以评定疗效。结果治疗组总有效65例(92.9%),对照组总有效46例(66.7%),治疗组显著高于对照组(P<0.05);两组患者治疗后血栓前体蛋白及血液流变学指标均有明显改变,但治疗组患者治疗后血栓前体蛋白及血液流变指标较治疗前明显降低且优于对照组(P<0.05);治疗组与对照组相比,患者日常生活能力评分、认知功能评分明显提高,差异具有统计学意义(P<0.05)。结论丹参多酚酸盐联合奥拉西坦可有效降低血栓前体蛋白,改善高龄腔隙性脑梗死患者认知功能和生活质量。Objective To observe the efficacy of salvianolate combined with oxiracetam in the treatment of elderly pa-tients with lacunar cerebral infarction. Methods A total of acute lacunar infarction 139 patients aged ≥ 80 years from January 2013 to December 2016 were enrolled, and divided into two groups including treatment group（n=70） and control group（n=69）. The treatment group was treated with salvia salvianolate and oxiracetam as the basic treatment, and the control group was treated with oxiracetam alone. And 14 days were as a course of treatment. The levels of thrombus precursor protein and hemorheology, neurological deficit score, and the changes in daily living ability and cognitive function score in the two groups were observed before and after treatment to assess the efficacy. Results The total num-ber of effective in the treatment group was 65 cases （92.9%）. The total number of effective cases in the control group was 46 cases（66.7%）. And the total effective rate of the treatment group was significantly higher than that of the control group（P〈0.05）. The thrombosis precursor protein and hemorheology indicators in both groups were significantly changed after treatment. However, the thrombosis precursor protein and hemorheology indicators in the treatment group after treatment were significantly lower than those before treatment and better than those in the control group（P〈0.05）. The daily life ability score and cognitive function score of the treatment group were significantly higher than those of the control group, and there was significant difference between the two groups（P〈0.05）. Conclusion Salvianolate combined with oxiracetam can effectively reduce thrombus precursor protein and improve the cognitive function and quality of life of elderly patients with lacunar cerebral infarction.

关 键 词：腔隙性脑梗死 丹参多酚酸盐 奥拉西坦 血栓前体蛋白 老年人 

分 类 号：R743.33[医药卫生—神经病学与精神病学]