口腔扁平苔藓患者幽门螺杆菌感染状况分析  

Analysis of Helicobacter pylori infection in patients with oral lichen planus

作　　者：姚小武[1] 卢子正[1] 刘少飞[1] 

机构地区：[1]汕头大学医学院第二附属医院口腔科,广东汕头515041

出　　处：《口腔疾病防治》2017年第11期729-732,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：广东省科技计划项目(2013B021800260)

摘　　要：目的分析口腔扁平苔藓患者幽门螺杆菌感染状况,探索口腔扁平苔藓与幽门螺杆菌感染的相关性。方法收集口腔扁平苔藓患者(扁平苔藓组)69例和口腔黏膜慢性炎症患者(慢性炎症组)28例,在初诊时进行^(14)C-尿素呼气试验,其中32例患者(扁平苔藓组23例,慢性炎症组9例)同时检测血清抗幽门螺杆菌(Helicobacter pylori,Hp)抗体。结果扁平苔藓组^(14)C-尿素呼气试验阳性率为68.12%,慢性炎症组^(14)C-尿素呼气试验阳性率为46.43%,扁平苔藓组高于慢性炎症组,差异有统计学意义(χ~2=3.970,P=0.046)。23例口腔扁平苔藓患者中抗Hp抗体阳性检出率为52.17%,9例口腔黏膜慢性炎症患者Hp抗体阳性检出率为22.22%,差异无统计学意义(χ~2=2.358,P=0.125)。结论口腔扁平苔藓患者幽门螺杆菌感染率较高,口腔扁平苔藓与幽门螺杆菌感染可能有关。Objective To explore the correlation between oral mucosal lichen planus and Helicobacter pylori infection by analyzing the infection status of Helicobacter pylori in patients with oral mucosal lichen planus. Methods ^（14）C urea breath test was done in 69 patients with oral lichen planus and 28 patients with chronic inflammation of oral mucosa. Detection of serum anti Helicobacter pylori antibody was done in 32 patients（23 with oral lichen planus and 9 with chronic inflammation of oral mucosa） at the same time. Results The positive rate of ^（14）C-urea breath test was 68.12%in patients with oral lichen planus and 46.43% in chronic inflammation of oral mucosa. There was significant difference between the 2 groups（χ~2=3.970, P=0.046）. The positive rate of anti Helicobacter pylori antibody was 52.17% in patients with oral lichen planus and 22.22% in chronic inflammation of oral mucosa, and there was no significant difference between the 2 groups（χ~2=2.358, P=0.125）. Conclusion The prevalence of Helicobacter pylori infection in patients with oral lichen planus is higher, and there is a relevance between oral lichen planus and Helicobacter pylori infection.

关 键 词：口腔扁平苔藓 幽门螺杆菌 ^(14)C-尿素呼气试验 抗HP抗体 相关性 

分 类 号：R781.5[医药卫生—口腔医学]