Functional tumor imaging based on inorganic nanomaterials  

作　　者：Jiangfeng Du Xiao Zhang Liang Yan Rui Chen 

机构地区：[1]School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University [2]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences [3]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China [4]College of Materials Sciences and Opto-Electronic Technology, University of Chinese Academy of Sciences

出　　处：《Science China Chemistry》2017年第11期1425-1438,共14页中国科学（化学英文版）

基　　金：supported by the Ministry of Science and Technology of China (2016YFA0201600);the National Natural Science Foundation of China (21477029);the Chinese Academy of Sciences (XDA09040400);Beijing Key Laboratory of Environmental Toxicology (2015HJDL01);the State Key Laboratory of Integrated Management of Pest Insects and Rodents (ChineseIPM1613)

摘　　要：Inorganic nanomaterials have attracted substantial research interest due to their unique intrinsic physicochemical properties. We highlighted recent advances in the applications of inorganic nanoparticles regarding their imaging efficacy, focusing on tumor-imaging nanomaterials such as metal-based and carbon-based nanomaterials and quantum dots. Inorganic nanoparticles gain excellent in vivo tumor-imaging functions based on their specific characteristics of strong near-infrared optical absorption and/or X-ray attenuation capability. The specific response signals from these novel nanornaterials can be captured using a series of imaging techniques, i.e., optical coherence tomography （OCT）, X-ray computed tomography （CT） imaging, two-photon luminescence （TPL）, photoacoustic tomography （PAT）, magnetic resonance imaging （MRI）, surface-enhanced Raman scattering （SERS） and positron emission tomography （PET）. In this review, we summarized the rapid development of inorganic nanomaterial applications using these analysis techniques and discussed the related safety issues of these materials.Inorganic nanomaterials have attracted substantial research interest due to their unique intrinsic physicochemical properties.We highlighted recent advances in the applications of inorganic nanoparticles regarding their imaging efficacy, focusing on tumor-imaging nanomaterials such as metal-based and carbon-based nanomaterials and quantum dots. Inorganic nanoparticles gain excellent in vivo tumor-imaging functions based on their specific characteristics of strong near-infrared optical absorption and/or X-ray attenuation capability. The specific response signals from these novel nanomaterials can be captured using a series of imaging techniques, i.e., optical coherence tomography(OCT), X-ray computed tomography(CT) imaging, two-photon luminescence(TPL), photoacoustic tomography(PAT), magnetic resonance imaging(MRI), surface-enhanced Raman scattering(SERS) and positron emission tomography(PET). In this review, we summarized the rapid development of inorganic nanomaterial applications using these analysis techniques and discussed the related safety issues of these materials.

关 键 词：imaging gold nanoparticles carbon nanotube GRAPHENE quantum dots TOXICITY 

分 类 号：TB383.1[一般工业技术—材料科学与工程]