改良丝线结扎法建立大鼠牙周病模型的实验研究  

Modified Thread Ligation Establishes Rat Periodontal Disease Model

作　　者：吕晗 韩冬 宋宁[1] 苏鑫[1] 毕良佳[1] 

机构地区：[1]哈尔滨医科大学附属第四医院口腔科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2017年第32期6257-6259,6319,共4页Progress in Modern Biomedicine

基　　金：黑龙江省卫生计生委科研课题(2016-116)

摘　　要：目的:探讨改良丝线结扎法建立大鼠牙周病模型的可行性。方法:本实验创新一种新的手段,利用玻璃离子水门汀结合传统丝线结扎法建立大鼠牙周病模型,即在丝线结扎大鼠第一磨牙之后,在大鼠磨牙牙颈部丝线附近堆砌有黏着性的玻璃离子水门汀制造利于丝线固定的外形高点并同时稍微垫高咬合面,制造咬合创伤,加快牙周病的发生发展。结果:改良丝线结扎法建立牙周病模型的成功率为95%,相比传统丝线结扎发的65%,具有更高的成功率,模型建立更稳定,相比现有各种改良方法操作更简便易行。结论:改良丝线结扎法相比传统丝线结扎法建立大鼠牙周病模型具有更高的稳定性和成功率。Objective： To explore the feasibility of establishing a rat model of periodontal disease by the method of modified silk suture. Method： A new method of the innovation, using of glass ionomer cement to establish a rat model of periodontal disease with traditional silk ligation, after the ligation of rat first molars in the vicinity of rat molar tooth neck threads are piled glass ionomer cement adhesive manufacturing for fixed shape and slightly high silk pad the ocelusal surface, making occlusal trauma, accelerate the occurrence and development of periodontal disease. Results： The success of modified silk ligation model of periodontal disease rate was 95%, compared with the traditional silk ligature of the 65%, has a higher success rate, model is more stable, compared with the existing various improved methods of operation more easy. Conclusion： Compared with the traditional method, the method of improving the periodontal disease in the rat model of periodontal disease is more stable and successful.

关 键 词：牙周病 WISTAR大鼠 丝线结扎 玻璃离子 牙槽骨 

分 类 号：R-33[医药卫生] R781.4