肺大细胞癌蛋白标志物的表达及临床意义  

The Expression and Clinical Significance in of Protein Markers Pulmonary Large cell Carcinoma

作　　者：马媛 战忠利[2] 孙保存[2] 赵永和 胡早秀[4] 

机构地区：[1]昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明650500 [2]天津市肿瘤医院病理科,天津300060 [3]昆明医科大学法医学院病理教研室,云南昆明650500 [4]云南省肿瘤医院病理科昆明医科大学第三附属医院病理科,云南昆明650118

出　　处：《昆明医科大学学报》2017年第9期30-34,共5页Journal of Kunming Medical University

基　　金：云南省应用基础研究计划基金资助项目(2013FZ072);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(2013FB117)

摘　　要：目的探讨肺大细胞癌蛋白标志物的表达及临床意义.方法检测肺大细胞癌蛋白标志物的表达并分型,分析各种蛋白标志物敏感性和特异性,统计各型肺大细胞癌淋巴结转移率及EGFR突变率的差异.结果肺大细胞癌可不同程度表达CK7、TTF1、Napsin A、CK5/6、p63、SOX2、p40、Cg A和Syn9种蛋白标志物,并根据各种蛋白标志物的表达情况将肺大细胞癌分为腺癌型、鳞癌型和干细胞型;CK7、TTF1、Napsin A对肺大细胞癌腺癌型的敏感性分别为100%、63.33%、76.67%,特异性分别为62.5%、100%、100%.CK5/6、p63、SOX2、p40对肺大细胞癌鳞癌型的敏感性分别为100%、87.5%、87.5%、87.5%,特异性分别为73.33%、83.33%、96.67%、96.67%;各型肺大细胞癌淋巴结转移率差异无统计学意义(P>0.05);各型肺大细胞癌EGFR突变率差异有统计学意义(P<0.05),干细胞型>腺癌型>鳞癌型.结论检测肺大细胞癌蛋白标志物并对其分型是有必要的,其有利于为临床判断预后及制定合理、有效的个体化治疗方案;腺癌型蛋白标志物的优劣顺序为Napsin A>TTF1>CK7,鳞癌型蛋白标志物的优劣顺序为SOX2=p40>p63>CK5/6.Objective To investigate the expression and clinical significance in of protein markers pulmonarylarge cell carcinoma（ PLCC）. Methods We detected the expression of protein markers of PLCC, and classifiedthe PLCC. We also evaluated the sensibility and specificity of the protein markser.Results The PLCC expresseddifferent protein markers：CK7,TTF1,NapsinA,CK5/6,p63,SOX2,p40,CgA and Syn. The sensibility andspecificity of CK7,TTF1,NapsinA was 100%,63.33%,76.67% and 62.5%,100%,100%. The sensibility andspecificity of CK5/6,p63,SOX2,p40 was 100%,87.5%,87.5%,87.5% and 73.33%,83.33%,96.67%,96.67%. The difference of lymph node metastasis rate of every type of pulmonary large cell carcinoma had nostatistical significance（ 〉0.05）,the difference of mutation rate of EGFR of every type of pulmonary large cellcarcinoma was statistically significant（ 〈0.05）, stem carcinoma〉adenocarcinoma〉squamous carcinoma.Conclusion It is necessary to detect protein markers of pulmonary large cell carcinoma and their classification. It ishelpful to clinical prognosis and to establish reasonable and effective individualized treatment.The sequence number ofthe sensibility and specificity to adenocarcinoma is NapsinA〉TTF1〉CK7, to squamous carcinoma isSOX2=p40〉p63〉CK5/6.

关 键 词：大细胞癌 蛋白标志物 分型 敏感性 特异性 个体化治疗 

分 类 号：R734[医药卫生—肿瘤]