急性胰腺炎患者血清SOCS-3水平的变化及其临床意义  

Dynamical changes and significance of serum SOCS-3 in patients with acute pancreatitis

作　　者：赵振中[1] 谢中华[1] 汪铁军[1] 郑元秀[1] 黄芳芳[1] 

机构地区：[1]杭州市余杭区第二人民医院内二科,杭州311121

出　　处：《中华胰腺病杂志》2017年第5期294-297,共4页Chinese Journal of Pancreatology

摘　　要：目的观察急性胰腺炎（AP）患者血清SOCS－3的变化，探讨其临床意义。方法选择2015年2月至2016年12月杭州余杭区第二人民医院收治的AP患者75例，根据病情严重程度分为轻度AP（MAP）40例，中、重度AP（MSAP＋SAP）35例。采用酶联免疫吸附试验法（ELISA）检测患者入院第1、3、5、7天血清SOCS－3、IL－6及TNF－α水平，选择年龄、性别等相匹配的同期30名健康体检者作为对照组。结果AP患者入院后第1天组血清SOCS－3、IL－6、TNF－α水平均较对照组明显升高（P〈0.01或〈0.05）。随着发病时间延长，AP患者血清SOCS－3、IL－6、TNF－α水平均逐渐升高，至第5天达峰值，第7天开始下降，但仍高于入院第1天。MSAP＋SAP组患者血清SOCS－3、IL－6、TNF－α水平均较MAP组显著升高，差异有统计学意义（F＝112.80，P＝0.001；F＝170.21，P＝0.000；F＝112.82，P＝0.000），两组不同时间点的差异亦均有统计学意义（F＝258.38，P＝0.000；F＝4.82，P＝0.000；F＝5.52，P＝0.001）。此外，AP患者血清SOCS－3水平与IL－6、TNF－α水平均呈显著正相关（r值分别为0.785、0.828，P值均〈0.01）。结论SOCS－3参与AP患者早期过度的炎症反应，并呈现动态变化。对SOCS－3和IL－6、TNF－α的监测可能有助于AP的临床分型和预后判断。Objective To investigate the dynamical changes of serum SOCS-3 in patients with acute pancreatitis （AP） and discuss the potential clinical significance.MethodsSeventy-five patients with AP admitted in Yuhang District Second People′s Hospital of Hangzhou City from February 2015 to December 2016 were selected, who were divided into 2 groups according to disease severity： 40 cases in mild AP （MAP） group and 35 cases in moderate and severe AP （MSAP＋ SAP） group. The levels of serum SOCS-3, IL-6 and TNF-α were determined by enzyme linked immunosorbent assay（ELISA）on the 1, 3, 5 and 7 day after admission. Thirty healthy people who were age and gender matched were included in the normal control group.ResultsThe levels of serum SOCS-3, IL-6 and TNF-α in AP patients on the 1 day after admission were significantly increased than that in the control group （P〈0.01 or P〈0.05）, which were gradually increased with the time, peaked on the 5 day and then started to decrease on 7 day after admission which was still higher than that on the 1 day after admission. The levels of serum SOCS-3, IL-6 and TNF-α in MSAP＋ SAP group were significantly higher than that in MAP group （P〈0.01）, and there were significant differences （F=112.80, P=0.001; F=170.21, P=0.000; F=112.82, P=0.000）. Significant differences were also found among different time points between two groups （F=258.38, P=0.000; F=4.82, P=0.000; F=5.52, P=0.001）. Additionally, the significantly positive correlations of SOCS-3 with IL-6 and TNF-α were found （r=0.785, r=0.828, both P〈0.01）. ConclusionsSOCS-3 may participate in early excessive inflammatory reactions in AP. Dynamic detection of SOCS-3 may be helpful for AP clinical classification and prognosis evaluation.

关 键 词：胰腺炎 SOCS-3 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R576[医药卫生—消化系统]