NOTUM基因与消化系统肿瘤的研究进展  

Research progress NOTUM gene in digestive svstem tumors

作　　者：胡翀[1] 张珂诚 高云鹤[1] 梁文全[1] 崔建新[1] 郗洪庆[1] 陈凛[1] 

机构地区：[1]解放军总医院普通外科

出　　处：《中国研究型医院》2017年第5期14-16,共3页Chinese Research Hospitals

基　　金：国家自然科学基金(81272698)

摘　　要：消化系统肿瘤严重影响了人类的健康,在世界呈现高发病率和高死亡率的现象,很多患者确诊都在中晚期,至今仍没有消化系统肿瘤早期筛查的可靠肿瘤标志物。有研究认为NOTUM基因在消化系统肿瘤中表达较高,可以作为消化系统肿瘤潜在的标志物。NOTUM基因先前的名称叫LOC147111,是一种特殊的磷脂酰聚糖磷脂酶,属于α糖磷水解酶属,能够有效影响Wnt信号通路,在肿瘤的形成及发展中起到重要的作用。近年来,有研究表明,NOTUM基因与消化系统肿瘤的发生发展有重要的联系,本文就NOTUM基因与消化系统肿瘤的研究进展做一概述。Digestive system tumors have seriously affected human health, showing high incidence and high mortality in the world. Many patients have been diagnosed in the late stage and still have no reliable tumor markers for early screening of digestive system tumors. Studies have suggested that the NOTUM gene is highly expressed in digestive system tumors and can be used as a potential marker for digestive system tumors. The NOTUM gene formerly known as LOC147111 is a special phosphatidylcholase, which belongs to the a/P hydrolase, which can effectively affect the Wnt signaling pathway and play an important role in tumor formation and development. In recent years, studies have shown that notum gene and the occurrence and development of digestive system tumors have an important link, this article discusses NOTUM gene and digestive system research progress to do an overview.

关 键 词：NOTUM基因 WNT信号通路 消化道肿瘤 

分 类 号：R735[医药卫生—肿瘤]