稳定同位素标记苏丹红Ⅰ-D_5的合成研究  

Synthesis of Sudan Ⅰ-D_5 Labeled with Stable Isotope

作　　者：卢浩[1] 孙雯[1] 徐仲杰[1] 

机构地区：[1]上海化工研究院技术开发中心,上海200062

出　　处：《化学试剂》2017年第11期1225-1228,共4页Chemical Reagents

基　　金："十二五"后科技支撑计划项目(2015-BAK45B01-20)

摘　　要：以廉价易得的苯-D6为起始原料,经硝化、还原、重氮化、偶合生成苏丹红Ⅰ-D5。以消耗的苯-D6计算,苏丹红Ⅰ-D5的总收率可达82.2%。采用1HNMR和ESI-MS等确定产品结构信息,产品的同位素丰度为99.1 atom%D,纯度为99.5%。该化合物可作为食品安全检测领域非法添加物质苏丹红Ⅰ检测的稳定同位素内标试剂。This work presents an efficient and convenient synthesis method of sudan Ⅰ-D5 with benzene-D6 as the common substrate,which is mainly obtained via nitration,reduction,diazotization and a coupling reaction.The yields of sudan Ⅰ-D5 was 82. 2%based on benzene-D6 consumed.The product＇s structures were confirmed by1 HNMR and ESI-MS.The chemical purity of this product is 99. 5% and deuterium isotopic enrichment of this product is 99. 1 atom% D. The compound could be used in the field of food safety testing as stable isotope internal standard reagent.

关 键 词：合成 稳定同位素 苏丹红Ⅰ-D5 食品安全 

分 类 号：TQ431.6[化学工程]