依达拉奉联合他汀类药物对缺血性脑卒中患者血清同型半胱氨酸、C反应蛋白、血脂水平的影响  

Effect of edaravone combined with statins on serum homocysteine,C-reactive protein and lipid levels in patients with ischemic stroke

作　　者：陆云南[1] 华烨[1] 冯志强[1] 马涛[1] 何培成 吴双双[2] 许红[1] LU Yunnan;HUA Ye;FENG Zhiqiang;MA Tao;HE Peicheng;WU Shuangshuang;XU Hong(Department of Neurology, Wuxi Second People＇s Hospital Affiliated to Nanjing Medical University,Wuxi, Jiangsu,2 14000;Jiangss People＇s Hospital, Nanjing, Jiangss, 210000)

机构地区：[1]南京医科大学附属无锡市第二人民医院神经内科,江苏无锡214000 [2]江苏省人民医院,江苏南京210000

出　　处：《实用临床医药杂志》2017年第19期27-30,共4页Journal of Clinical Medicine in Practice

基　　金：2015年江苏省干部保健科研课题(BJ15018)

摘　　要：目的观察缺血性脑卒中患者在给予依达拉奉联合他汀类药物治疗后血清同型半胱氨酸(Hcy)、C反应蛋白(CRP)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL)和低密度脂蛋白胆固醇(LDL-C)水平变化。方法 63例脑卒中患者分为2组,对照组27例给予瑞舒伐他汀,观察组36例在对照组治疗基础上给予依达拉奉治疗。检测体内Hcy、TG、TC、HDL及LDL-C水平变化,同时在治疗前与治疗14 d后填写脑卒中量表NIHSS、日常生活能力Barthel指数自评表、焦虑自评表(SAS)及抑郁自评表(SDS)。结果观察组Hcy、CRP及LDL-C水平显著低于对照组,HDL显著高于对照组。观察组患者在治疗14 d后总有效率达88.89%,显著高于对照组的77.78%。观察组患者Barthel指数显著高于对照组,SAS、SDS指数均显著低于对照组(P<0.05)。结论依达拉奉联合瑞舒伐他汀可显著提高缺血性脑卒中患者的治疗效果,优化患者预后及生活能力。ObjectiveTo analyze the effect of edaravone combined with statins on levels of serum homocysteine（Hcy）, C reactive protein （CRP） and total cholesterol （TC）, triglyceride （TG）, high density lipoprotein （HDL）, low density lipoprotein cholesterol （LDL C） in patients with ischemic stroke. MethodsA total of 63 patients with ischemic stroke in our hospital were divided into two groups, 27 cases in control group were given atorvastatin, and 36 patients in the observation group were given edaravone treatment in addition. The levels of Hcy, TG, TC, HDL and low LDL C were detected. At the same time, stroke scale of NIHSS, Barthel index of daily living ability, Self Anxiety Scale （SAS） and Self Depression Scale （SDS） were recorded at 14 days before and after treatment. ResultsThe observation group had lower Hcy, CRP and LDL C levels, while higher HDL level. Total effective rate in the observation group was significantly higher than the control group （88.89% vs. 77.78%, P〈0.05）. The observation group had higher Barthel index and lower SAS, SDS scores than the control group（P〈0.05）. ConclusionEdaravone combined with atorvastatin can significantly improve patients＇ treatment outcomes, and improve prognosis and life ability.

关 键 词：缺血性脑卒中 依达拉奉 同型半胱氨酸 C反应蛋白 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]