阿司匹林联合氯吡格雷对脑梗死患者同型半胱氨酸、超敏C反应蛋白的影响及预后分析  

Effects of aspirin combined with clopidogrel on Hcy and hs-CRP in patients with cerebral infarction and analysis prognosis

作　　者：冯志强[1] 陆云南[1] 许红[1] 马涛[1] 刘宇敏[1] 吴双双[2] 华烨[1] FENG Zhiqiang;LU Yunnan;XU Hong;MA Tao;LIU Yumin;WU Shuangshuang;HUA Ye(Department of Neurology, The Affiliated Wuxi Second People′s Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214000;Jiangsu People′ Hospital, Nanjing, Jiangsu, 210000)

机构地区：[1]南京医科大学附属无锡市第二人民医院神经内科,江苏无锡214000 [2]江苏省人民医院,江苏南京210000

出　　处：《实用临床医药杂志》2017年第19期38-40,43,共4页Journal of Clinical Medicine in Practice

基　　金：2015年江苏省干部保健科研课题(BJ15018)

摘　　要：目的观察阿司匹林联合氯吡格对脑梗死患者血清同型半胱氨酸、超敏C反应蛋白的影响及预后疗效评价。方法选取急性脑梗死患者68例。观察组39例给予阿司匹林联合氯吡格雷口服;对照组29例给予阿司匹林口服。观察2组患者治疗效果、治疗前后血清同型半胱氨酸、超敏C反应蛋白的变化情况及2组患者治疗前后神经缺损功能NIHSS评分。结果2组患者治疗7 d后Hcy及hs-CRP均明显下降,且观察组患者降低更为明显。2组患者治疗后NIHSS评分均下降,但2组NIHSS分值并无显著差异。在临床治疗21 d后,2组患者ESS、ADL评分均有显著改善,且观察组脑梗死改善程度显著优于对照组(P<0.05)。结论阿司匹林联合氯吡格雷可以显著降低脑梗死患者血清同型半胱氨酸及超敏反应C蛋白水平,改善患者预后。ObjectiveTo analyze the effects of aspirin combined with clopidogrel on Hcy and hs CRP in patients with cerebral infarction. MethodsA total of 69 patients with cerebral infarction in our hospital were divided into two groups, patients in observation group with 39 cases were treated with aspirin combined with clopidogrel, and control group with 29 cases treated with aspirin. The therapeutic effects of two groups, the changes of serum Hcy, hs CRP and NIHSS scores before and after treatment were observed. ResultsHcy and hs CRP levels were significantly decreased in the observation group and the control group after seven days of treatment. However, the observation group was significantly lower. After treatment, NIHSS score decreased in both groups, however, there was no significant difference in NIHSS in two groups. The ESS and ADL score were significantly improved, and observation group was better than the control group after 21 days of treatment（P〈0.05）. ConclusionAspirin combined with clopidogrel can significantly reduce serum Hcy and hs CRP levels, and improve the prognosis in patients with cerebral infarction.

关 键 词：脑梗死 阿司匹林 氯吡格雷 预后 

分 类 号：R73[医药卫生—肿瘤]