多羟基1,2-二取代苯并咪唑的选择性合成和抗氧化性质研究  

The Chemoselective Synthesis of 1,2-Disubstituted Benzoimidazoles and Their Antioxidant Properties for Radical Scavenging

作　　者：周佳[1] 方秋生[1] 余治宇 宋智彬[1] 

机构地区：[1]江西师范大学化学化工学院,教育部功能有机小分子重点实验室,江西南昌330022

出　　处：《江西师范大学学报（自然科学版）》2017年第4期424-427,共4页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：江西省自然科学基金(2016BAB213070);江西省教育厅科技计划(GJJ13214)资助项目

摘　　要：苯并咪唑衍生物是一类具有多种生理活性的化合物,在医药学中应用广泛.化合物分子中含有羟基会有助于提高其对自由基的清除能力.但是在传统合成路线上,对于羟基等易氧化基团需在合成过程中先对羟基进行保护.采用一步合成实现了多羟基取代的1,2-二取代苯并咪唑类化合物的合成,对合成出的1,2-二取代苯并咪唑类化合物进行了抗自由基活性研究.在ABTS、DPPH自由基清除实验中,多羟基取代的1,2-二取代苯并咪唑都显示出了较好的活性.Benzoimidazole derivatives are a class of compounds with a variety of physiological activity which are widely used in medicine. The hydroxyl group in the compounds can enhance the biological activities in antioxidation. But hydroxyl group often needs protection in the traditional procedure due to the sensitive to air or oxidant.Herein we report a convenient and efficient method for preparation of 1,2-disubstituted benzoimidazoles without the protection of the hydroxyl group. And the 1,2-disubstituted benzoimidazole with muti hydroxyl group showed good activity at antioxidation and radical scavenging which is confirmed though ABTS and DPPH radical scavenging experiments.

关 键 词：苯并咪唑 抗氧化 自由基清除 

分 类 号：O621.32[理学—有机化学]