血清瘦素、BDNF水平与血管性认知功能障碍相关性研究  

Correlation between serum levels of keptin and BDNF and cognitive function in patients with vascular cognitive impairment

作　　者：毕尚青 骆振宇 翟亮[1] 曾纪斌[2] 黄汝成[3] 

机构地区：[1]深圳市宝安区中医院老年病科,深圳518101 [2]深圳市宝安区中医院糖尿病科,深圳518101 [3]深圳市宝安区中医院脑病科,深圳518101

出　　处：《新医学》2017年第11期784-789,共6页Journal of New Medicine

基　　金：深圳市宝安区医疗卫生科研项目(2016CX005)

摘　　要：目的探讨血管性认知功能障碍(VCI)患者血清瘦素、脑源性神经营养因子(BDNF)与认知功能的相关性。方法将缺血性脑血管患者按有无VCI分为VCI组(56例)及对照组(32例),对2组进行简易精神状态检查量表(MMSE)、蒙特利尔认知评价量表(Mo CA)评估,并应用ELISA检测患者血清瘦素和BDNF水平,比较2组的检测结果。MMSE、Mo CA评分结果与瘦素、BDNF的相关性采用Pearson相关分析,血管性痴呆(Va D)的多因素分析采用非条件Logistic回归分析。结果 VCI组血清瘦素和BDNF水平均低于对照组(P均<0.05);VCI患者血清瘦素和BDNF水平与MMSE、Mo CA评分呈正相关(r值为0.371、0.402,P均<0.01)。年龄越大、血清瘦素与BDNF水平越低者发生Va D的可能性越大(P均<0.05)。结论瘦素、BDNF与VCI密切相关,可能是VCI的血清学标志物。Objective To investigate the correlation bet^veen serum levels of leptin and brain-derivedneurotrophic factor （BDNF） , and cognitive function in patients with vascular cognitive impairment （VCI）.Methods According to the presence of VCI, all patients with ischemic cerebrovascular disease were dividedinto the VCI （n = 56） and control groups （n =32）. Mini-mental state examination （MMSE） and MontrealCognitive Assessment （MoCA） were performed in two groups. The serum levels of leptin and BDNF were quantitatively measured by ELISA and statistically compared bet^veen two groups. The correlation between the MMSE , MoCA scores and serum levels of leptin and BDNF was analyzed using Pearson correlaMulti-variate correlation of vascular dementia （VaD） was performed by using Logistic regression analysis. Re-sults In the VCI group , the serum levels of leptin and BDNF were significantly lower compared with those in the control group （ both P 〈 0. 05 ） . The serum levels of leptin and BDNF were positively correlated with the MMSE and MoCA scores in the VCI patients （r = 0.371 and 0. 402 , both P 〈0.01）. The ones who were elder and with lower serum levels of leptin and BDNF might have greater risk of VaD （ all P 〈0. 05）. Conclusion Serum levels of leptin and BDNF are intimately correlated with the incidence of VCI , which are probably the rum markers of VCI.

关 键 词：血管性认知功能障碍 缺血性卒中 瘦素 脑源性神经营养因子 非痴呆性血管性认知功能障碍 血管性痴呆 

分 类 号：R749.13[医药卫生—神经病学与精神病学]