应用群体药动学模型制订患儿抗癫痫给药方案的药学会诊实践  

Practice of pharmacy consultation on dosage regimen for pediatric epilepsy patient with PPK model

作　　者：李彦萍[1,2] 孙洲亮 林玮玮[2] 

机构地区：[1]厦门大学附属第一医院药学部,福建厦门361000 [2]福建医科大学附属第一医院药学部,福建福州350004

出　　处：《药学实践杂志》2017年第6期559-561,共3页Journal of Pharmaceutical Practice

摘　　要：目的为优化癫痫患儿卡马西平和丙戊酸给药方案提供参考。方法药师参与1例脑外伤术后癫痫患儿的药学会诊,总结分析其使用卡马西平和丙戊酸血药浓度异常的原因,应用群体药动学模型为患儿调整给药剂量,并评价笔者团队所建模型的预测能力。结果患儿病情得到了有效控制。结论药师应用群体药动学模型优化抗癫痫药物治疗方案,为临床合理用药提供参考。Objective In order to provide a reference for optimizing the dosage regimen of carbamazepine and valproate in pediatric epilepsy patients.Methods Pharmacist consulted one pediatric epilepsy patient with traumatic brain injury for post operation epilepsy treatments. The abnormal plasma concentration of carbamazepine and valproic acid was analyzed with the population pharmacokinetic （PPK） model built by this team. New medication regimen was proposed and the predictive capability of this model was evaluated.Results Seizures in this patient have been effectively controlled. Conclusion Pharmacist can optimize the antiepileptic drug treatment with PPK model and achieve rational drug use clinically.

关 键 词：群体药动学 卡马西平 丙戊酸 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]