不同程度晶状体混浊对视网膜血氧饱和度测量结果的影响  

The effect of lens opacity on the measurement of retinal oxygen saturation

作　　者：伍蒙爱 毛剑波 王君 徐小琼 沈丽君 

机构地区：[1]温州医科大学附属眼视光医院杭州院区,310020

出　　处：《中华眼底病杂志》2017年第6期601-604,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：浙江省重点学科建设计划项目（2016cxxk2）;温州市公益性科技计划项目（Y20150257）

摘　　要：目的观察不同程度晶状体混浊对视网膜血氧饱和度测量结果的影响。方法横断面研究。不同程度晶状体混浊的44例患者44只眼纳入研究。其中，男性23例，女性21例。年龄48～84岁，平均年龄（71.8±10.3）岁。患眼平均最佳矫正视力0.65±0.22；平均眼压（14.2±4.3）mmHg（1 mmHg=0.133 kPa）；平均等效球镜度数（？0.05±2.10）D。采用视觉质量分析系统测量患眼眼内客观散射指数（OSI），并根据OSI对晶状体混浊程度进行分级。OSI＜1.0为1级，表示晶状体基本透明；1.0≤OSI＜3.0为2级，表示早期白内障；3.0≤OSI＜7.0为3级，表示进展期白内障；OSI＞7.0为4级，表示成熟期白内障。采用视网膜血氧饱和度分析仪拍摄患眼不同波长光束下的眼底像，应用配套软件自动计算得出视网膜动脉、静脉血氧饱和度值。采用Pearson相关分析法对视网膜血氧饱和度与年龄、眼压、等效球镜度数、OSI之间的相关性进行分析。对比分析不同程度晶状体混浊患眼之间的视网膜血氧饱和度差异。结果患眼平均视网膜动脉、静脉血氧饱和度及动静脉血氧饱和度差值分别为（90.70±6.46）%、（47.34±13.51）%、（43.36±10.09）%。相关性分析结果显示，视网膜动脉、静脉血氧饱和度及动静脉血氧饱和度差值与年龄、眼压、等效球镜度数均无线性相关性（P＞0.05）。视网膜动脉（r=？0.462，P=0.002）、静脉血氧饱和度（r=？0.500，P=0.001）与OSI呈负相关；动静脉血氧饱和度差值与OSI呈正相关（r=0.373，P=0.013）。44只眼中，晶状体混浊程度为1级11只眼，2级9只眼，3级14只眼，4级10只眼。晶状体混浊程度不同分级患眼视网膜动脉、静脉血氧饱和度比较，差异有统计学意义（F=5.340、4.710，P=0.003、0.007）；动静脉血氧饱和度差值比较，差异无统计学意义（F=2.048，P=0.123）。4级晶状体混浊患眼的视网膜动脉、静脉�ObjectiveTo analysis the effect of lens opacity on the measurement of retinal vessel oxygen saturation.MethodsThis was a cross sectional study. Forty four eyes of 44 patients with different degrees of lens opacity were enrolled. There were 23 males and 21 females. The patients aged from 48 to 84 years, with the mean age of （71.8±10.3） years. The mean best corrected visual acuity was 0.65±0.22. The mean intraocular pressure was （14.2±4.3） mmHg （1 mmHg=0.133 kPa）. The mean equivalent spherical degree was （？0.05±2.10） D. The opitical quality analysis system was applied to measure intraocular objective scattering index （OSI） caused by lens opacity. According to the OSI, the opacity of lens was divided into four groups. Patients with OSI value ＜1.0 was grouped to level 1, which indicated that the lens were basically transparent; patients with OSI value between 1.0 and 3.0 was grouped to level 2, which indicated early cataract; patients with OSI value between 3.0 and 7.0 was grouped to level 3, which indicated progressive cataract; patients with OSI value ＞7.0 was grouped to level 4, which indicated the mature stage of cataract. The retinal oximeter Oxymap T1 was used to capture the fundus images under different wavelengths. Pearson correlation analysis was used to analyze the correlation between retinal oxygen saturation and age, intraocular pressure, equivalent spherical degree and OSI. One way ANOVA was used to analyze the difference of retinal oxygen saturation among groups.ResultsThe mean retinal arterial oxygen saturation, venous oxygen saturation and arteriovenous difference was （90.70±6.46）%, （47.34±13.51）%, （43.36±10.09）%, respectively. The correlations of retinal arterial oxygen saturation, venous oxygen saturation and arteriovenous difference with age, intraocular pressure, equivalent spherical degree was not statistically significant （all P＞0.05）. The retinal arterial oxygen saturation and venous oxygen saturation was negatively correlated with OSI （r=？

关 键 词：白内障 血氧测定法 散射测浊法和比浊法 

分 类 号：R774.1[医药卫生—眼科]