科特迪瓦阿比让55例结膜鳞状细胞癌结果分析（英文）  

Conjunctival squamous cell carcinoma:outcome analysis of 55 cases in Abidjan

作　　者：Rokia Coulibaly Berete Thierry Yves Constant Sowagnon Abokan Joel Konan Sylvanius Beossin Koui Sandrine Kouassi Kouakou Simon N'Dri Dede Adama Fanny 

机构地区：[1]特雷什维尔教学医院,眼科 [2]尤布贡教学医院,眼科 [3]特雷什维尔教学医院,病理科 [4]特雷什维尔教学医院,影像科

出　　处：《国际眼科杂志》2017年第12期2187-2192,共6页International Eye Science

摘　　要：目的:研究55例结膜鳞状细胞癌的流行病学、临床特点,以及艾滋病毒对其发病情况的影响。方法:横断面研究,纳入就诊于阿比让特雷什维尔大学医院眼科的54例55眼结膜鳞状细胞癌患者。收集的数据包括书面问卷、眼科检查、病理检查、HIV血清学检查、治疗情况(手术及化疗)、随访情况和预后。结果:患者年龄为7~75(平均42.28)岁。女性占53%。发病到就诊时间6~60(平均18)mo。患者平均随访29mo。共有53%(29眼)无视功能。54例患者中42例HIV阳性,28例为HIV1感染,4例为HIV2感染,10例为混合感染。这42例患者中28例进行了淋巴细胞分类检查,结果显示33%的患者CD4细胞计数<200/m L,19%的患者200~500/mL,12%的患者>500/m L。42眼(76%)为侵袭性分化型鳞状细胞癌,13眼(24%)为原位癌。40例(73%)局部肿瘤进行了肿块切除,其中6例进行了术后局部辅助化疗。社会经济情况分析显示39%的患者经济情况较差。结论:HIV感染是结膜鳞状细胞癌发病的危险因素,尤其是在撒哈拉以南的非洲。这一疾病不良预后可能与患者社会经济情况较差,我们治疗机构中医疗资源不足,抗肿瘤药物治疗经费较少有关,HIV感染也对疾病有一定影响。AIM： To determine epidemiological, clinical profile and access the impact of HIV in its occurrence in 55 eyes of conjunctival squamous cell carcinoma.METHODS： A cross sectional study, 55 eyes of 54 patients affected by conjunctival squamous cell carcinoma（CSCs）presented in the Ophthalmology Department of University Hospital of Treichville in Abidjan were included. Data were collected： interrogatories, ophthalmologic examination, histopathologic finding, HIV serology, therapeutic（surgery, chemotherapy）, follow-up and prognosis. The statistical analysis was performed using Epi-info version 6.0 and a statistical comparison was performed using the Chi-square test with a significance threshold set at 5%. RESULTS： The age ranged 7-75y（median age 42.28）. A female predominance was observed with a sex-ratio of 0.89. The average consultation period was 18mo, with extremes ranging from 6-60mo. Physically 53% of our eyes（29 eyes）presented a functional loss of the eye. And 42 out of the 54 patients were HIV positive with 28 cases of HIV1 infection, 4 cases of HIV2 infection and 10 cases of HIV1 and 2 co-infection. Lymphocyte typing was performed for 28 out of 42 patients with CD4 cell counts 〈200/mL in 33% of cases, between 200 and 500 in 19% of cases and 500/mL in 12% of cases. It was noted 42 cases（76%）of invasive differentiated squamous cell carcinoma, and 13 cases（24%）of squamous cell carcinoma in situ. Forty localized tumors underwent tumor resection（73%）associated with a postoperative adjuvant topical chemotherapy in 6 cases. Socioeconomic status showed 39% of patients were economic cally inactive. The average follow up period of our patients was 29mo.CONCLUSION： HIV infection is a risk factor for the occurrence of conjunctival squamous cell carcinoma especially in sub-Saharan Africa where the fight against the infection although boosted in these recent years is far from achieving all objectives. The poor prognosis of conjunctival squamous cell carcinoma reflects the low socioecon

关 键 词：上皮癌 鳞状细胞 获得性人免疫缺陷病毒 

分 类 号：R739.7[医药卫生—肿瘤]