颌骨骨髓炎中IL-17、IL-6和IL-1β的表达  

Expressions of IL-17,IL-1β,and IL-6 in Osteomyelitis of Jaw

作　　者：王俊英 撒国良 刘志康 何三纲[1] 

机构地区：[1]武汉大学口腔医学院口腔生物医学教育部重点实验室,湖北武汉430079

出　　处：《口腔医学研究》2017年第10期1082-1085,共4页Journal of Oral Science Research

基　　金：国家自然科学基金资助项目(编号:81371126)

摘　　要：目的:对化脓性及放射性下颌骨骨髓炎患者病变骨组织进行免疫组化染色,检测IL-17、IL-6和IL-1β在2种不同病因的颌骨骨髓炎中的表达情况。方法:取化脓性及放射性颌骨骨髓炎患者病变骨组织做样本,HE染色观察局部骨组织的结构,并用免疫组织化学方法检测局部组织中IL-17、IL-6和IL-1β的表达情况,与健康骨组织作对比。结果:IL-17、IL-6在化脓性颌骨骨髓炎中表达水平明显升高,而放射性颌骨骨髓炎局部组织中IL-17、IL-6的表达与正常组织无显著差异。化脓性与放射性颌骨骨髓炎局部骨组织中IL-1β的表达水平与正常骨组织相比有显著差异,而在2种骨髓炎中的表达差异不明显。结论:IL-17、IL-6在化脓性颌骨骨髓炎的成骨与破骨失衡中可能有更重要的作用,而与放射性颌骨骨髓炎关系不密切。IL-1β是颌骨骨髓炎发生的重要因素。Objective： To investigate the expression of IL--17, IL--6, and IL--1β in osteomyelitis of different eti- ology in patients with pyogenic and radioactive osteomyelitis of mandible. Methods： Lesion bone was obtained from patients who were diagnosed as suppurative or radioactive osteomyelitis of mandible. Hematoxylin eosin staining was used to observe the structure of local bone, and the expression levels of IL--17, IL--6, and IL--1β in local tis- sues were detected by immunohistochemistry. Results： IL--17 and IL--6 was significantly increased in pyogenic os- teomyelitis. However, the expression of IL--17 and IL--6 was insignificant different between radiation osteomyeli- tis and normal bone. The expression levels of IL--1β in the local of pyogenic and radioactive osteornyelitis were both increased compared to the normal bone tissues. Conclusion： IL--17 and IL--6 may play a more important role in imbalance between bone formation and bone resorption in the suppurative osteomyelitis, whereas, it has marginal effect on the radioactive osteomyelitis. IL-1β may involve in the occurrence of osteomyelitis of jaws.

关 键 词：化脓性颌骨骨髓炎 放射性颌骨骨髓炎 白细胞介索-17 白细胞介素-6 白细胞介素-1Β 

分 类 号：R782.32[医药卫生—口腔医学]