奥美拉唑钠联合生长抑素治疗上消化道大出血的疗效分析  

Effectiveness analysis of omeprazole sodium combined with somatostatin in treatment of massive hemorrhage of the upper digestive tract

作　　者：马东凯[1] 

机构地区：[1]吉林省前卫医院消化科,长春130012

出　　处：《中华灾害救援医学》2017年第11期621-624,共4页Chinese Journal of Disaster Medicine

摘　　要：目的探讨奥美拉唑钠联合生长抑素治疗上消化道大出血的疗效,为临床急救及合理用药提供循证医学依据。方法选取2015-12至2017-02吉林省前卫医院消化科收治的上消化道大出血患者152例,按照治疗方法的不同分为两组,在常规急救基础上给予奥美拉唑钠治疗者为对照组(n=76);在常规急救、给予奥美拉唑钠治疗基础上,联合应用生长抑素治疗者为观察组(n=76)。比较两组的输血量、止血时间、血红蛋白、红细胞计数及临床疗效。结果观察组的输血量(t=82.414,P<0.001)、止血时间(t=24.311,P<0.001)低于对照组,血红蛋白(t=-41.936,P<0.001)、红细胞计数(t=-16.681,P<0.001)高于对照组,差异均有统计学意义;观察组显效39例(51.32%),有效32例(42.10%),无效5例(6.58%);对照组显效31例(40.79%),有效23例(28.95%),无效22例(28.95%),观察组疗效优于对照组,差异有统计学意义(Z=-2.393,P=0.017)。结论上消化道大出血急救时给予生长抑素联合艾司奥美拉唑钠,具有很好的止血效果,且给药方便安全,是上消化道大出血急救的有效方法之一。Objective The objective of this study was to investigate the effectiveness of omeprazole sodium combined with somatostatin in treatment of massive upper gastrointestinal hemorrhage, and to provide a basis for its use as a treatment modality. Methods A total of 152 patients suffering from massive hemorrhage of upper digestive tract treated in Jilin Qian Wei Hospital between December 2015 and February 2017 were selected, and divided into two groups based on different treatment methods, with 76 cases in each group. The control group was given omeprazole sodium on the basis of routine emergency treatment; the observation group was provided with somatostatin on the basis of routine emergency treatment and omeprazole sodium. Then blood transfusion volume, time to achieve hemostasis, hemoglobin, red blood cell count and clinical efficacy were compared between the two groups. Results The volume of blood transfusion （t=82.414, P〈0.001） and time to achieve hemostasis （t=24.311, P〈0.001） of the observation group were lower than those of the control group, hemoglobin （t=-41.936, P〈0.001） and red blood cell count （t=-16.681, P〈0.001） were higher than those of the control group, the differences were statistically significant. In the observation group, 39 cases （51.32%） were significantly effective, 32 cases （42.10%） effective, 5 cases （6.58%） ineffective; and in the control group, 31 cases （40.79%） were significantly effective, 23 cases （28.95%） effective, 22 cases （28.95%） ineffective. The curative effect of the observation group was better than that of the control group, and the difference was statistically significant （Z=-2.393, P=0.017）. Conclusions Omeprazole sodium combined with somatostatin has an effective hemostatic effect and is ease of administration, which is effective in the emergency treatment of massive upper gastrointestinal bleeding.

关 键 词：上消化道大出血 急救 奥美拉唑钠 生长抑素 

分 类 号：R735.3[医药卫生—肿瘤]