肠道菌群对中药有效成分的生物转化研究进展  

Research Progress of Biotransformation on Effective Ingredients of Chinese Medicine Via Intestinal Bacteria

作　　者：刘玉峰[1] 胡延喜[1] 王志萍[1] 韩彬[2] 朱丽君[1] 孙珊珊[1] 卢晓丹 

机构地区：[1]辽宁大学药学院,辽宁沈阳110036 [2]黑龙江中医药大学药学院,黑龙江哈尔滨150040 [3]沈阳市120中学化学组,辽宁沈阳110036

出　　处：《辽宁大学学报（自然科学版）》2017年第4期325-332,共8页Journal of Liaoning University：Natural Sciences Edition

基　　金：国家自然科学基金青年项目(81403177);沈阳市科技局应用基础项目(F12-277-1-14)

摘　　要：近年来,肠道菌群对中药有效成分的生物转化研究一直是国内外学者关注的热点.中药多数是以口服的形式进入消化道,而肠道难以吸收、在肠道内滞留时间较长的中药化学成分则更易受到肠道菌群的作用,因而肠道内微生物对中药的代谢发挥着重要作用.通过查阅近15年国内外文献,主要针对苷类化合物,生物碱类化合物,黄酮类化合物,苯丙素类化合物,有机酸类化合物在肠道菌群作用下的生物转化进行分析归纳总结,为进一步研究、开发利用中药提供参考和依据.In the recent years,biotransformation on the active ingredients of Traditional Chinese Medicine via intestinal bacterias has been drawing the attention of domestic and overseas scholars.Most of Traditional Chinese Medicine come into the digestive tract by oral administration.Chemical constituents which are difficult in intestinal absorption or have long retention time in the gastrointestinal tract are more easier to be affected by intestinal flora.Therefore,microorganisms in the intestinal tract play an important role in the metabolism of Traditional Chinese Medicine.According to domestic and international literatures in recent 15 years,the biotransformation of glycosides,alkaloids,flavonoids,phenylpropanoids and someorganic acids under the effect of intestinal flora were analyzed and summarized to provide information for the further research and development of Traditional Chinese Medicine.

关 键 词：肠道菌群 有效成分 生物转化 

分 类 号：R914.1[医药卫生—药物化学]