肿瘤坏死因子-α与转化生长因子-β_1和癌症相关性乏力的关系  

The relationship between cancer-related weakness and TNF-α and TGF-β_1

作　　者：苏树伟[1] 崔海银[1] 路晓波[1] 岳韦名[2] 李林[2] 

机构地区：[1]山东省交通医院急诊科,济南250031 [2]山东大学齐鲁医院胸外科

出　　处：《中国临床保健杂志》2017年第6期659-661,共3页Chinese Journal of Clinical Healthcare

基　　金：山东省医药卫生科技发展计划项目(2014WS0324)

摘　　要：目的探讨肿瘤坏死因子-α(TNF-α)与转化生长因子-β_1(TGF-β_1)和癌症相关性乏力的关系。方法选择92例癌症伴有轻、中度乏力患者为观察组,92例健康体检者为对照组。采用流式细胞仪测定血清TNF-α、TGF-β_1的含量。结果治疗前,患者血清TNF-α为(27.35±12.08)ng/L,显著高于健康对照组的(12.04±5.44)ng/L(t=11.080,P<0.001)。患者治疗后TNF-α明显降低为(18.57±10.32)ng/L(t=5.369,P<0.001)。治疗前,患者血清TGF-β_1为(39.26±10.65)ng/L,显著高于健康对照组的(16.53±6.37)ng/L(t=17.570,P<0.001)。患者治疗后TGF-β_1明显降低为(25.98±7.87)ng/L(t=8.952,P<0.001)。结论癌症相关性乏力的发病机制可能由于血清TNF-α、TGF-β_1等细胞因子的表达增强引起的。Objective To investigate the relationship between cancer-related weakness and TNF-α and TGF-β_1. Methods A total of 92 cancer patients with light and mediumly weak were enrolled in observation group,and 92 cases of healthy physical examination were enrolled in control group. The serum TNF-α and TGF-β_1 were detected by using flow cytometry. Results Before treatment,the serum TNF-α levels of observation group was( 27. 35 ± 12. 08)ng/L,which was significantly higher than that of control group( 12. 04 ± 5. 44) ng/L( t = 11. 080,P < 0. 001). And after treatment,the TNF-α of observation group reduced to( 18. 57 ± 10. 32) ng/L( t = 5. 369,P < 0. 001). Before treatment,the serum TNF-β_1 levels of observation group was( 39. 26 ± 10. 65) ng/L,which was significantly higher than that of control group( 16. 53 ± 6. 37) ng/L( t = 17. 570,P < 0. 001),which was reduced to( 25. 98 ± 7. 87) ng/L( t =8. 952,P < 0. 001) after treatment. Conclusion The pathogenesis of cancer-related weakness may be due to the increase of serum TNF-α and TGF-β_1.

关 键 词：肺肿瘤 虚弱 肿瘤坏死因子Α 转化生长因子Β1 

分 类 号：R730.2[医药卫生—肿瘤]