抑郁症患者抗抑郁治疗无效后换药方法文献综述  

Literature review of the switch antidepressants when antidepressant treatment is ineffective

作　　者：冯新新(综述) 王克勤(审校)[1] 

机构地区：[1]济宁医学院,济宁医学院精神卫生学院,济宁272067

出　　处：《济宁医学院学报》2017年第3期209-213,共5页Journal of Jining Medical University

摘　　要：初次抗抑郁药治疗后,约2/3抑郁患者症状未能得到有效缓解。另外,还有部分患者因无法耐受的副反应、经济状况以及个人偏好等因素无法继续原药治疗。因此,换用抗抑郁药是临床上非常普遍的现象。本文参考了大量国内外相关文献资料,对初次抗抑郁药治疗失败后换药的有效性、换药时机、更换药物选择、换药策略、换药风险等问题进行综述,以供临床医师参考。About two-thirds of patients with major depressive disorder do not relieve effectively after the initial antidepressant monotherapy treatment.Additionally,some patients can not continue the original treatment due to the intolerable side-effects,financial problems,personal preferences and other factors.Therefore,switching antidepressants is very common in actual clinical practice.At present,according to a great number of foreign relevant literatures,the major problems of switching antidepressants are summarized,including the efficacy,the appropriate timing and antidepressant,the switching strategies,the risks and so on,which provide the references for psychiatrists.

关 键 词：抗抑郁药 换药策略 戒断反应 5-HT综合征 药物清洗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]