乌梅丸联合驻车丸方保留灌肠治疗脾虚湿热型放射性直肠损伤的临床研究  

Clinical Study of Using Wumei Pill Combined Zhuche Pill Retention Enema in the Treatment of Spleen-deficiency and Dampness-heat Type Radiation Rectal Injury

作　　者：聂欣宁 陆霞[1] 常玉坤[2] NIE Xinning;LU Xia;CHANG Yukun;et al(Traditional Chinese Medicine Hospital of Tangshan City, Hebei Tangshan 063000, China;The People＇s Hospital of Tangshan City ,Tangshan Hebei 063000, China)

机构地区：[1]唐山市中医医院,河北唐山063000 [2]唐山市人民医院,河北唐山063000

出　　处：《四川中医》2017年第10期80-83,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：2016年度河北省中医药管理局科学技术课题(编号:2016180)

摘　　要：目的:观察乌梅丸联合驻车丸方保留灌肠治疗脾虚湿热型放射性直肠损伤疗效的临床疗效及对患者功能状态及血清IL-1、IL-6、TNF-α水平的影响。方法:选取符合纳入标准的患者120例,随机均分三组,治疗组给予采用乌梅丸联合驻车丸方保留灌肠;对照组1采用康复新液保留灌肠;对照组2给予硫糖铝口服混悬液保留灌肠。观察干预前后症状观察指标、直肠镜粘膜充血水肿情况、功能状态及血清IL-1、IL-6、TNF-α水平的变化。结果:治疗组、对照1组,对照2组临床疗效总有效率分别为90.00%、77.50%、75.00%,治疗组分别与对照组在临床疗效总有效率比较均有显著性差异(P<0.05)。治疗组分别与对照组在KPS评分、血清IL-1、IL-6、TNF-α水平方面比较均有显著性差异(P<0.05)。结论:乌梅丸联合驻车丸方保留灌肠能较好地改善脾虚湿热型放射性直肠损伤临床症状,改善直肠粘膜情况明显,明显的提高患者的功能状态及生活质量。Objective：To observe the clinical curative effect of Wumei Pill combined with Zhuche Pill for the treatment of retention enema with spleen deficiency and dampness heat type radiation rectal injury and the influence of the state and the level of IL-1,IL-6,TNF-alpha level in patients.Methods：120 patients met the inclusion criteria,were randomly divided into three groups,treatment group was treated by Wumei Pill combined Zhuche Pill retention enema;the controlled group 1 treated with Kangfuxin retention enema;the controlled group 2 was given Sucralfate Oral Suspension retention enema.The changes of symptoms and signs,rectal mucosa congestion and edema,functional status,serum IL-1,IL-6 and TNF-levels were observed before and after intervention.Results：The total effective rate of the treatment group and the controlled group 1,the controlled group2 was 90%,77.50%,75% respectively,the treatment group compared with the controlled group in total clinical efficacy was significantly different efficiency（P〈0.05）.The treatment group were compared with the controlled group in the KPS score,serum IL-1,IL-6,TNF-levels were significantly different（P〈0.05）.Conclusion：Wumei Pill combined with Zhuche Pill retention enema can effectively improve the spleen deficiency symptoms of rectal injury,rectal mucosa is significantly improved,significantly improve functional status and quality of life of patients.

关 键 词：乌梅丸 驻车丸 康复新液 放射性直肠损伤 

分 类 号：R73[医药卫生—肿瘤]