正常血清尿酸与非酒精性脂肪性肝病的相关性研究  

Association between the normal range of serum uric acid and nonalcoholic fatty liver disease

作　　者：范能光[1] 彭亮 夏振华[2] 张丽娟[2] 王育璠[1] 徐浣白 彭永德[1] 

机构地区：[1]上海交通大学附属第一人民医院内分泌代谢病科,200080 [2]上海交通大学附属第一人民医院松江分院内分泌科

出　　处：《中国糖尿病杂志》2017年第11期970-973,共4页Chinese Journal of Diabetes

基　　金：国家自然科学基金青年项目(81400785)

摘　　要：目的研究普通人群中正常SUA与非酒精性脂肪性肝病(NAFLD)的关系。方法收集22209例正常SUA体检者的临床和生化资料并通过腹部B超诊断NAFLD。按照是否存在NAFLD分为非NAFLD(Non-NAFLD)组和NAFLD组,按照性别特异的SUA四分位数分为4组(Q1~Q4)。结果本研究人群中NAFLD的患病率为20.9%。随着SUA水平升高,各组年龄、BMI、SBP、DBP、TG、TC、LDL-C、Scr、谷丙转氨酶(ALT)和谷草转氨酶(AST)均升高,而HDL-C降低(P<0.001);Q1组至Q4组,NAFLD患病率逐渐升高(分别为12.3%、16.0%、23.0%和32.6%,P<0.001);校正性别、年龄、BMI、血压、血脂后,多元Logistic回归分析显示,Q2~Q4组NAFLD患病风险较Q1组分别增加24%、43%和94%(P<0.001)。结论普通人群正常范围内SUA的升高与NAFLD密切相关,可能是其发生的独立危险因素。Objective To investigate the association between normal-ranged serum uric acid（SUA）and nonalcoholic fatty liver disease（NAFLD）in general population. Methods A total of 22209 subjects with normal SUA were recruited to undergo physical and biochemical exa minations.B ultrasonography was used to diagnose NAFLD.According to the presence of ultrasound,the subjects were divided into non NAFLD（Non-NAFLD）group and NAFLD group.All subjects were divided into 4 groups（Q1~Q4）according to sex-specific SUA quartiles. Results The prevalence of NAFLD was 20.9% in this population.Age,BMI,SBP,DBP,TG,TC,LDL-C,Scr,ALT and AST were significantly elevated with the increase of SUA levels（P 〈0.001）,while HDL-C was obviously deceased.The proportion of NAFLD increased in participants with higher SUA quartiles（12.3%,16.0%,23.0%and 32.6%,respectively,P〈0.001）.Logistic regression analysis showed that the risk of NAFLD were increased by 24%,43%and 94%in participants of the second,third and fourth SUA quartile,respectively,as compared with participants in the first quartile. Conclusion SUA within normal range is significantly and independently associated with NAFLD in general population.

关 键 词：尿酸 非酒精性脂肪性肝病 

分 类 号：R575.5[医药卫生—消化系统]