3.0TMRI预测三阴性乳腺癌  

3.0T MRI in predicting triple negative breast cancer

作　　者：江森[1] 洪又佳[2] 肖莹[1] 张凡 李仰康[1] 

机构地区：[1]汕头大学医学院附属肿瘤医院放射科,广东汕头515041 [2]汕头大学医学院附属肿瘤医院超声科,广东汕头515041 [3]汕头大学医学院附属肿瘤医院肿瘤研究实验室,广东汕头515041

出　　处：《中国医学影像技术》2017年第11期1656-1660,共5页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨3.0T MR影像特征中能够预测三阴性乳腺癌(TNBC)的危险因素。方法收集接受3.0T MR检查并经病理证实的乳腺癌病例191例,其中三阴型乳腺癌25例(TNBC组),非三阴性乳腺癌166例(非TNBC组),比较2组年龄、病灶形态、肿块数目、大小、形状、边缘、强化特征、T2WI信号、时间-信号强度曲线(TIC)、ADC值、瘤周血管的差异,并采用单因素及多因素分析法进行统计学分析。结果与非TNBC组比较,TNBC组病灶多表现为边缘光滑(P=0.023)、圆形(P=0.001)肿块,增强扫描多呈环形强化(P<0.001),病灶T2WI多呈高信号(P=0.003),ADC值相对较高(P=0.022),瘤周血管增多(P=0.046)。其中肿块强化特征、T2WI信号、ADC值及瘤周血管纳入Logistic回归模型,为预测TNBC的独立危险因素(P均<0.05),4个因素联合预测TNBC的ROC曲线下面积为0.840。结论肿块环形强化、T2WI高信号、ADC值相对较高、瘤周血管增多是预测TNBC的独立危险因素。Objective To evaluate the related factors in 3.0 T MR imaging features for predicting triple negative breast cancer（TNBC）.Methods Totally 191 patients with breast cancer confirmed by histopathology were enrolled,among them25 were TNBC（TNBC group）,while the other 166 were non-TNBC（non-TNBC group）.All patients underwent 3.0 T MR examination.Patient age,tumor size,shape,margin,enhancement pattern,signal intensity on T2 WI,time-intensity curve（TIC）,ADC value,and peritumoral vessel between the two groups were compared.Univariate and multivariate Logistic regression analyses were used to predict the related factors.Results Compared with non-TNBC group,smooth margin（P=0.023）,round mass（P=0.001）,rim enhancement（P0.001）,high signal intensity on T2 WI（P=0.003）,higher ADC value（P=0.022）and increased peritumoral vessel（P=0.046）were significantly associated with TNBC.Further multivariate Logistic regression analysis identified four independent risk factors of TNBC（all P0.05）,including enhancement pattern,signal intensity on T2 WI,ADC value and increased peritumoral vessel.The area under ROC curve of combination of the 4 factors was 0.840.Conclusion Rim enhancement of mass,high signal intensity on T2 WI,higher ADC value,and increased peritumoral vessels are independent risk factors in predicting TNBC.

关 键 词：乳腺肿瘤 三阴性乳腺癌 磁共振成像 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]