肾上腺腺瘤宽体探测器CT灌注成像特点  

Wide detector CT perfusion imaging features of adrenal adenoma

作　　者：赵莹[1] 刘爱连[1] 刘静红[1] 邓锡佳 郭丹[1] 刘晓冬[1] 刘义军[1] 方鑫[1] 刘泽群[1] 

机构地区：[1]大连医科大学附属第一医院放射科,辽宁大连116011

出　　处：《中国医学影像技术》2017年第11期1674-1679,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的探讨肾上腺皮质腺瘤宽体探测器CT灌注成像特点。方法回顾性分析21例经病理证实的肾上腺皮质腺瘤患者的宽体探测器CT扫描资料。CT灌注(CTP)扫描采用16cm探测器覆盖的轴扫模式,ASiR-V50%,注射对比剂6s后开始行CTP数据采集,共采集26期图像,在第22s、51s及153s获取动脉期、静脉期及延迟期增强图像。测量肾上腺腺瘤(A组)和对侧正常肾上腺结合部(B组)的血流量(BF)、血容量(BV)、平均通过时间(MTT)、达峰时间(TP)及表面通透性(PS)值。比较2组间各参数值的差异,并评价辐射剂量。应用ROC曲线分析CT灌注参数对肾上腺腺瘤的诊断效能。结果 A组的BV、MTT及PS值均低于B组(P均<0.05),2组间BF、TP值差异无统计学意义(P均>0.05)。以BV、MTT及PS值诊断肾上腺腺瘤的ROC曲线下面积(AUC)分别为0.780、0.762及0.831,以PS值1.37ml/(100g·min)为阈值诊断腺瘤的敏感度为95.2%,特异度为81.0%。平扫、CTP(含增强三期)的有效辐射剂量(ED)分别为(3.20±0.57)、(19.98±1.95)。结论宽体探测器CT灌注成像可为诊断肾上腺皮质腺瘤提供高质量常规三期强化图像,同时提供有效的定量灌注数据。PS值对腺瘤有较高诊断效能。Objective To investigate the features of CT perfusion（CTP）parameters of adrenal adenoma（AA）using wide detector CT.Methods The wide detector CT scanning data of 21 patients with pathologically confirmed AA were retrospectively analyzed.CT perfusion（CTP）imaging was performed with the axis mode covering by 16 cm detector and ASiR-V50%.The image acquisition of CTP was performed after 6 sof injection of contrast media.Totally 26 consecutive volume acquisitions were contained.The arterial,venous and delayed phase images were obtained at the time of 22 s,51 s and 153 safter the injection,respectively.The blood flow（BF）,blood volume（BV）,mean transit time（MTT）,time to peak（TP）and permeability of surface（PS）values of AA（group A）and contralateral normal adrenal gland（group B）were measured.All parameters between the two groups were compared,and the radiation dose was assessed.ROC curves were used to assess the diagnostic efficiency of CT perfusion parameters for AA.Results BV,MTT and PS values of group A were statistically lower than those of group B（all P0.05）.There was no statistical difference of BF and TP values between the two groups（both P0.05）.The area under the ROC curve（AUC）of BV,MTT and PS was 0.780,0.762 and 0.831,respectively.The sensitivity and specificity of diagnosis of AA was 95.2% and 81.0%,respectively,when the threshold of PS was 1.37 ml/（100 g·min）.The effective dose（ED）of CT plain and CTP（including three-phase enhanced scan）were（3.20±0.57）mSv and（19.98±1.95）mSv.Conclusion Wide detector CT perfusion imaging can provide high-quality conventional three-phase enhanced images for diagnosis of AA,and provide effective quantitative perfusion data at the same time.PS value shows strong capability for diagnosis of AA.

关 键 词：体层摄影术 X线计算机 灌注成像 肾上腺腺瘤 

分 类 号：R736.6[医药卫生—肿瘤] R814.42[医药卫生—临床医学]