癫痫患者发作间歇期人格的改变及Logistic回归分析  

The characteristics of personality changes and Logistic regression analysis of related factors in epilepsy patients

作　　者：何霞[1] 滕军放[1] 崔璨[1] 温丽君[1] 李东瑞[1] 

机构地区：[1]郑州大学第一附属医院神经内科,河南郑州450052

出　　处：《中国实用神经疾病杂志》2017年第20期1-5,共5页Chinese Journal of Practical Nervous Diseases

基　　金：国家自然科学基金青年科学基金;项目编号:81400931

摘　　要：目的研究癫痫患者发作间歇期人格改变的特点,并对相关的影响因素进行Logistic回归分析。方法选取2013-07—2014-12郑州大学第一附属医院神经内科和神经外科收治的95例癫痫患者,均行脑电图、头CT或MRI等检查,90例健康对照患者来自于我院工作人员及志愿者。采用艾森克人格问卷(Eysenck personality questionnaire,EPQ)成人版对发作间歇期的癫痫患者和健康对照组进行人格评价,通过计算机后处理软件获得精神质(psychoticism,P)、内-外向(extra-introversion,E)、神经质(neurotisim,N)、掩饰度(lie,L)评分,采用单因素分析人格改变的相关因素,将单因素分析有意义的影响因素进行多因素Logistic回归分析。结果艾森克人格评分显示,癫痫组患者的精神质、神经质评分明显高于对照组(P<0.05),癫痫组患者的内-外向评分明显低于对照组(P<0.05),2组患者的掩饰度评分结果无显著性差异(P>0.05);单因素分析结果显示,不同年龄、病程、受教育程度的癫痫患者,其精神质、内-外向、神经质、掩饰度评分有显著性差异(P<0.05),而不同性别、发作类型、癫痫持续发作状态史及不同类型抗癫痫药物使用的患者4个维度的评分差异无统计学意义(P>0.05);多因素Logistic回归分析显示,精神质评分与病程独立相关(P<0.05);内-外向评分与受教育程度独立相关(P<0.05)。结论癫痫患者在发作间歇期存在人格改变,主要特点为内-外向评分降低,精神质和神经质评分增加。受教育程度是癫痫患者内-外向人格的独立危险因素,病程是癫痫患者精神质人格的独立危险因素。Objective To investigate the characteristics of the personality changes of epilepsy patients, and the related factors were analyzed by Logistic regression analysis. Methods 95 patients and 90 healthy controls were selected included on from July 2013 to December 2014 from in the department of neurology and neurosurgery of our hospital,and all patients were given re- ceived electroencephalogram, CT and MRI examination. 51 cases of healthy controls were come from our staff and volunteers. The personality changes of patients of epilepsy during onset of intermittent period and healthy controls were assessed by using Eysenck personality questionnaire （adult version）. The scores of psychoticism, extra-introversion, neurotisim, and lie were obtained by compute post-processing software. The related factors of personality changes were analyzed by using the single factor analysis, and the meaningful factors were analyzed by Logistic regression analysis. Results The Eysenck personality score showed that psychoticism and neuroticism score of epilepsy group were obviously higher than those of control group （P-0.05）, and the extro- version score of epilepsy group was significantly lower than the control group （P〈0. 05）, but the lie scores of the two groups showed no statistically significant difference （P-0. 05）. The results of single factor analysis showed that there were significant differences on the psychoticis, neuroticism, extroversion and lie scores among patients with different age, disease duration, and edu- cation level （P〈0. 05）, but there were no significant differences among different sexs, seizure type and history of status epileplicus,anti-epileptic drugs usage （P〉0.05）. The results of multiariable Logistic regression analysis showed that disease duration was independently correlated to P scores （P〈0. 05） ;while education level was correlated to E scores （P〈0. 05）. Conclusion There are personality changes during onset of intermittent period of patients with epilepsy, main

关 键 词：癫痫 发作间歇期 人格改变 艾森克人格问卷 影响因素 

分 类 号：R742.1[医药卫生—神经病学与精神病学]