尿激酶静脉溶栓治疗急性脑梗死的影响因素分析  

Analysis of the influence factors of thrombolytic therapy of urokinase in patients with acute cerebral infarction

作　　者：农媛[1] 肖海[1] 陈奎[1] 张泰鹏[1] 李秀芬[1] 

机构地区：[1]贵港市人民医院神经内科,广西贵港537100

出　　处：《中国实用神经疾病杂志》2017年第20期30-33,共4页Chinese Journal of Practical Nervous Diseases

基　　金：贵港市科研究与技术开发计划项目;编号:1607005

摘　　要：目的分析尿激酶静脉溶栓治疗急性脑梗死患者效果的影响因素,以早期评估溶栓治疗效果。方法 2012-01—2016-06贵港市人民医院收治的采用尿激酶静脉溶栓的129例急性脑梗死患者按溶栓治疗效果分为有效组及无效组,对2组间年龄、性别、嗜烟、嗜酒、糖尿病史、高血压史、卒中史、发病至溶栓治疗时间、入院至溶栓治疗时间、入院前NIHSS评分、治疗前MAP、治疗前LDL-C水平、房颤及动脉狭窄或闭塞等进行比较。结果单因素分析显示,有效组患者发病至溶栓治疗时间显著短于无效组,有高血压史、糖尿病史及动脉狭窄或闭塞的比例显著低于无效组(P<0.05)。多因素分析显示,发病至溶栓治疗时间、糖尿病史及动脉狭窄或闭塞等是影响急性脑梗死患者尿激酶静脉溶栓治疗效果的独立危险因素。结论发病至溶栓治疗时间越长,合并糖尿病及动脉狭窄或闭塞的急性脑梗死患者尿激酶静脉溶栓治疗效果不佳。Objective To analyze of the influence factors of thrombolytic therapy of urokinase in patients with acute cerebral infarction and assess the therapeutic effect. Methods From January 2012 to June 2016,129 patients with acute cerebral infarction treated with intravenous urokinase thrombolysis therapy were divided into effective group and ineffective group according to the effect of thrombolytic therapy with urokinase. The age, sex, smoking, drinking, diabetes, hypertension, stroke history, onset to treatment time, door to needle time, baseline NIHSS score, baseline MA, baseline LDL-C level, atrial fibrillation and arterial stenosis or occlusion were compared between the two groups. Results Univariate analysis showed that the time of onset to throm- bolysis was significantly shorter in the effective group, and the proportion of hypertension history, diabetes history and the propor- tion of arterial stenosis or occlusion were significantly lower in the effective group than in the ineffective group. Conclusion The effect of urokinase thrombolytic therapy was poor in the acute cerebral infarction patient with longer onset to treatment time, dia- betes history and arterial stenosis or occlusion.

关 键 词：急性脑梗死 尿激酶 静脉溶栓 影响因素 

分 类 号：R743.33[医药卫生—神经病学与精神病学]