阿托伐他汀钙联合氯吡格雷治疗短暂性脑缺血发作的疗效  

Curative effect of atorvastatin calcium combined with clopidogrel on transient ischemic attack

作　　者：李晓钟[1] 

机构地区：[1]开封市第二人民医院,河南开封475000

出　　处：《中国实用神经疾病杂志》2017年第20期77-80,共4页Chinese Journal of Practical Nervous Diseases

基　　金：开封市科技发展计划项目;编号:汴科鉴字【2014】第08号;开封市科技发展计划项目;编号:110322

摘　　要：目的观察阿托伐他汀钙与氯吡格雷联合治疗短暂性脑缺血发作(TIA)的疗效及对患者血清TC、TG与LDL-C水平影响。方法选取2014-03—2016-06开封市第二人民医院收治的TIA患者79例,按入院顺序分为观察组(n=40例)及对照组(n=39例)。对照组于基础治疗上加用阿托伐他汀钙,观察组于对照组基础上予以氯吡格雷治疗。(1)统计比较2组临床疗效;(2)比较2组治疗前后血清TG、TC、LDL-C水平;(3)比较2组治疗前后神经功能及生活质量;(4)统计比较2组不良反应发生率;(5)治疗后随访3个月,统计比较2组脑梗死发生率。结果 2组总有效率比较,观察组92.50%(37/40)明显高于对照组71.79%(28/39),差异有统计学意义(P<0.05);治疗前2组TC、LDL-C、TG水平比较,差异无统计学意义(P>0.05),治疗后,观察组TC、LDL-C、TG水平均低于对照组,差异有统计学意义(P<0.05);治疗前2组NIHSS评分、生活质量评分比较,差异无统计学意义(P>0.05),治疗后观察组NIHSS评分低于对照组,生活质量评分高于对照组,差异均有统计学意义(P<0.05);观察组不良反应总发生率17.50%(7/40)与对照组12.82%(5/39)比较,差异无统计学意义(P>0.05);观察组脑梗死发生率2.50%(1/40)明显低于对照组20.51%(8/39),差异有统计学意义(P<0.05)。结论阿托伐他汀钙与氯吡格雷联合治疗TIA疗效确切,能明显降低血脂水平及脑梗死发生率,提高患者神经功能及生活质量,且安全性较高。Objective To observe the curative effect of atorvastatin calcium combined with clopidogrel on transient ischemic attack and its effect on serum levels of TC,TG and LDL-C. Methods 79 cases of TIA patients from March 2014 to June 2016 in our hospital were divided into observation group （n=40 cases） and control group （n=39 cases） according to the order of admission. The control group was treated with atorvastatin calcium on the basis of basic treatment, and the observation group was trea- ted with clopidogrel on the basis of the control group. （1） Make statistical comparison of the clinical efficacy between the two groups;（2） before and after treatment,compare the serum TG,TC and LDL-C levels between two groups; （3） compare the nerve function and quality of life of two groups before and after treatment; （4） the incidence of adverse reactions of the two groups were recorded; （5） following up for 3 months after the treatment,make statistical comparison of the incidence rate of cerebral infarction in two groups. Results The total effective rate of the observation group was 92.50% （37/40） ,which was significantly higher than that of the control group 71.79% （28/39）（P〈0. 05）. Before treatment, there was no significant difference in the levels of TC, LDL-C and TG between the two groups（P〈0. 05）. After treatment, the levels of TC, LDL-C and TG in the observation group were lower than those in the control group（P〈0. 05）. Before treatment, there was no significant difference between two groups in the NIHSS score and quality of life score（P〈0. 05）. After treatment, the NIHSS score of the observation group was lower than that of the control group,and the quality of life score was higher than that of the control group（P〈0.05）. There was no significant difference in the total incidence of adverse reactions between the observation group 17.50% （7/40） and the control group 12. 82%（5/39）（P〈0. 05）. The incidence of cerebral infarction in the observation

关 键 词：阿托伐他汀钙 氯吡格雷 短暂性脑缺血发作 

分 类 号：R743.31[医药卫生—神经病学与精神病学]