神经节苷脂联合依达拉奉治疗对急性脑梗死患者神经功能及脑血管储备能力的影响  

Effect of gangliosides combined with edaravone on neurological function and cerebrovascular reserve capacity in patients with acute cerebral infarction

作　　者：朱亚兰[1] 吴湘军[1] 郑海燕[1] 

机构地区：[1]四川省广汉市人民医院神经内科,四川广汉618300

出　　处：《实用医院临床杂志》2017年第6期167-170,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨神经节苷脂联合依达拉奉治疗对急性脑梗死患者神经功能及脑血管储备能力的影响。方法 2015年2月至2016年10月我院收治的78例急性脑梗死患者,依据治疗方法不同分为对照组(实施依达拉奉注射液治疗)和联合组(在对照组基础上联合神经节苷脂治疗),观察两组白细胞介素-6(IL-6)、血清肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、美国国立卫生院脑卒中量表(NIHSS)评分、改良巴氏指数(BI)、大脑中动脉(MCV)血流速度、脉动指数(PI)、脑血管阻力(CVR)及药物安全性。结果治疗后两组IL-6、TNF-α、CRP、NIHSS评分、PI较治疗前明显降低,BI、MCV、CVR明显升高,且联合组各项指标改善较对照组明显(P<0.05);两组药物不良反应总发生率差异无统计学意义(P>0.05)。结论神经节苷脂联合依达拉奉治疗急性脑梗死患者,通过有效降低患者炎症因子水平、降低神经功能损伤及提高脑血管储备能力,达到改善患者预后生活质量的目的,是一种疗效确切、安全可靠的药物方案。Objective To investigate the effect of gangliosides combined with edaravone on the neurological function and cerebrovascular reserve capacity in patients with acute cerebral infarction （ACI）. Methods A total of AC178 patients admitted to our hospital from February 2015 to October 2016 were enrolled in the study. According to different treatment methods, they were divided into control group （treated with edaravone injection, n = 40） and combined group （treated with edaravone injection combined with gangliosides, n = 38）. The inflammatory factor of interleukin-6 （IL-6）, tumor necrosis factor alpha （TNF-α） and C reactive protein （CRP）, National Institutes of Health Stroke Scale （NIHSS） ,modified Barthel Index （BI） ,middle cerebral artery blood flow velocity （MCV）, pulsatility index （PI）, cerebral vascular resistance （CVR） and drug safety were observed in the two groups before and after treatment. Results After treatment,IL-6,TNF-α,CRP,NIHSS score and PI were significantly decreased while BI,MCV and CVR were significandy increased in both group when compared to before treatment, and the improvement in the combined group was better than that in the control group （ P 〉 0. 05 ）. There was no significant difference in the incidence of adverse drug reactions between the two groups （ P 〉 0. 05）. Conclusion Gangliosides combined with edaravone in the treatment of ACI can improve the quality of life of patients by reducing levels of inflammatory factors and neurological function damage as well as improving cerebrovascular reserve capacity. It is an effective ,reliable and safe regimen.

关 键 词：急性脑梗死 神经节苷脂 依达拉奉 疗效 

分 类 号：R743.33[医药卫生—神经病学与精神病学]