SRPX2的功能及其在肿瘤发生发展中的作用  

The Functional Roles of SRPX2 in Tumor Development and Progression

作　　者：张孟 索振河[1] 

机构地区：[1]郑州大学第一附属医院肿瘤科,郑州450052

出　　处：《中国生物化学与分子生物学报》2017年第11期1110-1114,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.81272824)~~

摘　　要：含sushi重复蛋白X连锁2(sushi repeat-containing protein X-linked 2,SRPX2)是一种分子质量约为53 k D,具有细胞外基质蛋白属性的硫酸软骨素蛋白聚糖,在大脑语言中枢的发育过程中发挥重要作用。目前研究发现,SRPX2在多种恶性肿瘤组织中呈高表达,参与肿瘤细胞的增殖、迁移、黏附和侵袭等生物学行为,促进肿瘤的发生和发展,与肿瘤患者的不良预后密切相关。另有研究显示,SRPX2可通过诱导内皮细胞迁移和血管网形成,从而促进血管生成。因此认为,SRPX2是一个潜在的肿瘤治疗靶点。本文对SRPX2的结构、生物学特征、相关疾病以及在肿瘤中的生物学作用及其机制进行综述。Sushi repeat-containing protein X-linked 2（SRPX2） is a chondroitin sulfate proteoglycan with a molecular weight of about 53 kD.As an extracellular matrix protein,it plays an important role during the development of the language center within the brain.It has been found that SRPX2 is overexpressed in a variety of malignant tumor tissues and its overexpression is closely related to the poor prognosis of patients.Increasing evidence indicated its roles in cell proliferation,migration,adhesion and invasion,which were all related to tumor progression.In addition,SRPX2 promotes angiogenesis by inducing endothelial cell migration and vascular network formation.Therefore,SRPX2 is a potential target for tumor therapy.This review summarizes the molecular structure,biological characteristics and possible molecular mechanisms for SRPX2.

关 键 词：含sushi重复蛋白X连锁2(SRPX2) 肿瘤 上皮间质转化 转移 黏着斑激酶 

分 类 号：R730.2[医药卫生—肿瘤]