PVT1在恶性肿瘤发生发展中的作用及机制  

The Role and Mechanism of PVT1 in Promoting Human Cancer Progression

作　　者：何奕 魏芳[1,2,3] 张姗姗 龚朝建[2,4] 郭灿[2,3] 李夏雨[5] 李小玲[1,2,3] 周鸣 熊炜[1,2,3] 李桂源 曾朝阳[1,2,3] 石磊[1,2,4] 

机构地区：[1]中南大学湘雅医学院附属肿瘤医院湖南省肿瘤医院,长沙410013 [2]中南大学肿瘤研究所卫生部癌变原理重点实验室,长沙410078 [3]中南大学湘雅医院教育部癌变与侵袭原理重点实验室,长沙410078 [4]中南大学湘雅二医院,长沙410011 [5]中南大学湘雅三医院湖南省非可控性炎症与肿瘤重点实验室,长沙410013

出　　处：《生物化学与生物物理进展》2017年第11期981-989,共9页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(81372907;81472531;81572787;81672683;81672993);湖南省自然科学基金(2015JJ1022)资助项目~~

摘　　要：长链非编码RNA在调节细胞的生长、分化及其他生物学过程中具有重要作用,且与恶性肿瘤等常见疾病密切相关.人类长链非编码RNA PVT1的编码基因由于位于染色体8q24这一脆性位点且临近癌基因MYC而受到广泛关注.浆细胞瘤可变异位基因1(PVT1)在多种肿瘤中高表达,是潜在的癌基因;PVT1也能因染色体断裂重排而与其他基因形成新的融合基因影响恶性肿瘤的表型;PVT1还可与MYC基因相互作用,通过多种途径参与恶性肿瘤细胞的增殖、凋亡等调控.本文对PVT1在恶性肿瘤发生发展中的作用及其机制进行综述.In recent years, long non-coding RNA is found to play an important role in the regulation of cell growth, differentiation and other biological functions, and is closely related to the occurrence and development of cancer. The long non-coding RNA gene, PVT1, located in the fragile chromosome 8q24 region has been widely concerned. LncRNA PVT1 is highly expresses in many types of cancer, and act as potential oncogene. It is commonly to form new fusion gene by chromosome break, and translocation, and regulation of tumor cell function; it also interact with MYC and participate in tumor cell proliferation, apoptosis by multiple pathways. However, the specific molecular mechanisms that occur in the development of cancer still need further research. In this paper, we summarized the features, functions and roles of PVT1 in human cancer.

关 键 词：恶性肿瘤 长链非编码RNA PVT1 MYC 

分 类 号：R73[医药卫生—肿瘤] Q7[医药卫生—临床医学]