消溃散联合复方甲硝唑漱口液治疗乳腺癌患者口服依维莫司所致口腔溃疡的临床研究  

Clinical Observation of Xiaokui Powder Combined with Compound Metronidazole Collutory Treating Everolimus-induced Oral Ulcer Patients with Breast Cancer

作　　者：肖寒 方乃青 邬晓敏 奚柯婧 李慧刚 

机构地区：[1]江南大学附属医院(无锡市第四人民医院)中西医肿瘤科,江苏214000 [2]江苏省无锡市查桥社区卫生服务中心内科,江苏214000

出　　处：《中国中西医结合杂志》2017年第11期1330-1333,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江苏省无锡市医管中心项目(No.YGZXM1403)

摘　　要：目的观察消溃散联合复方甲硝唑漱口液治疗依维莫司所致口腔溃疡的临床治疗效果。方法按照随机数字表法将30例口服依维莫司后出现口腔溃疡的乳腺癌患者随机分为治疗组和对照组,每组15例。对照组患者给予复方甲硝唑漱口液漱口,治疗组在此基础上给予消溃散外用,从出现口腔溃疡后24h开始用药,用药第1、3、5天进行溃疡面观察以及疼痛评分。记录所有患者口腔溃疡的治疗有效率、疼痛缓解程度、疼痛评分及溃疡愈合时间。结果治疗组口腔溃疡有效率为85.7%(12/14)高于对照组64.3%(9/14,P<0.05);治疗组疼痛缓解率[100.0%(14/14)]明显高于对照组[64.3%(9/14),P<0.05];与本组治疗前比较,对照组治疗后5天、治疗组治疗后3、5天疼痛评分降低(P<0.05)。与对照组比较,治疗后3、5天治疗组疼痛评分明显降低(P<0.05)。治疗组溃疡愈合时间(4.5±1.7)d短于对照组(7.2±2.3)d(P<0.05)。结论消溃散联合复方甲硝唑漱口液治疗依维莫司所致口腔溃疡能有效缓解疼痛程度,加快溃疡愈合时间。Objective To investigate the clinical efficacy of Xiaokui powder combined with com- pound metronidazole collutory on everolimus-induced oral ulcer. Methods Thirty cases of advanced breast cancer patients with everolimus-induced oral ulcer were assigned to treatment group and control group with 15 cases in each group according to the random number table. The patients in the control group were treated by compound metronidazole collutory. The patients in the treatment group were trea- ted by compound metronidazole collutory and Xiaokui powder. Two groups started medication from the oc- currence of oral ulcer within 24 hours.The ulcer surface and pain score were measured on day 1,3 and 5. The overall effective rate of oral ulcer healing,degree of pain relief, pain score and the healing time of o- ral ulcer were observed and recorded. Results In the treatment group,the response rate of oral ulcer healing was 85.7%（12/14） ,higher than 64.3% in the control group（9/14, P 〈0.05）.The pain remission rate of treatm ent group was 100 % （ 14/14 ）, which was significantly superior to that of the control group （9/ 14,64.3%） .Compared with the group before treatment, the pain scores on day 5 in the control group and on day 3,5 in the treatment group were decreased （P 〈0.05）.Compared with the control group, the pain score of the treatment group on day 3 and day 5 decreased significantly （P 〈0.05）.The average healing time of oral ulcer in treatment group was shorter than that of control group（P 〈0.05） .Conclusion The Xiaokui powder combined with compound metronidazole collutory could effectively relieve oral pain and accelerate ulcer healing time in treating everolimus-induced oral ulcer.

关 键 词：消溃散 复方甲硝唑漱口液 依维莫司 口腔溃疡 

分 类 号：R737.9[医药卫生—肿瘤] R781.5[医药卫生—临床医学]