五水头孢唑啉钠联合奥美拉唑肠溶胶囊治疗十二指肠炎性溃疡的临床效果  

Clinical effect of cefazolin sodium pentahydrate combined with omeprazole enteric-coated capsules on duodenal ulcer

作　　者：苏珍 

机构地区：[1]西藏自治区日喀则市人民医院消化内科,857000

出　　处：《中国医药》2017年第11期1699-1702,共4页China Medicine

摘　　要：目的 观察五水头孢唑啉钠联合奥美拉唑肠溶胶囊治疗十二指肠炎性溃疡的临床效果。方法 选取2016年1月到2017年1月西藏自治区日喀则市人民医院收治的十二指肠炎性溃疡且幽门螺杆菌检测阳性患者100例，完全随机分为对照组和观察组，各50例。对照组口服奥美拉唑肠溶胶囊20 mg/次，1次/d，疗程为4周；观察组在对照组基础上静脉滴注五水头孢唑啉钠2.0 g/次，1次/d，两药合并连续给药1周、口服药物继续1周。比较2组的腹痛消失时间、炎性指标、临床疗效和不良反应。结果 经治疗后观察组患者腹痛消失时间明显短于对照组，白细胞计数、红细胞沉降率、C反应蛋白水平均明显低于对照组［（2.8±0.8）d比（3.8±1.4）d、（4.6±1.0）×109/L比（5.3±1.3）×109/L、（18±4）mm/1 h比（21±4）mm/1 h、（7.8±1.3）mg/L比（9.8±1.7）mg/L］，差异均有统计学意义（均P〈0.05）。观察组治疗总有效率高于对照组［94.0%（47/50）比82.0%（41/50）］，差异有统计学意义（P＜0.05）。2组均无不良反应发生。结论 五水头孢唑啉钠联合奥美拉唑肠溶胶囊治疗十二指肠炎性溃疡的效果明显优于单用奥美拉唑肠溶胶囊。Objective To observe the clinical effect of cefazolin sodium pentahydrate combined with omeprazole enteric-coated capsules on duodenal ulcer. Methods Totally 100 duodenal ulcer patients with positive helicobacter pylori test admitted from January 2016 to January 2017 in Shigatse People′s Hospital of Tibet Autonomous Region were randomly divided into control group and observation group, with 50 cases in each group. The control group took omeprazole enteric-coated capsules 20 mg/time, 1 time/d for 4 weeks. The observation group had intravenous administration of cefazolin sodium pentahydrate 2.0 g/time, 1 time/d combined with oral administration of omeprazole enteric-coated capsules for 1 week, and took omeprazole enteric-coated capsules for another week. Abdominal pain disappear time, inflammatory indicators, clinical efficacy and adverse reactions were analyzed. Results After treatment, abdominal pain disappear time in observation group was significantly shorter than that in control group; leucocyte count, erythrocyte sedimentation rate and C-reactive protein in observation group were significantly lower than those in control group[（2.8±0.8）d vs （3.8±1.4）d, （4.6±1.0）×109/L vs （5.3±1.3）×109/L, （18±4）mm/1 h vs （21±4）mm/1 h, （7.8±1.3）mg/L vs （9.8±1.7）mg/L]（P〈0.05）. The total effective rate in observation group was significantly higher than that in control group[94.0%（47/50） vs 82.0%（41/50）]（P〈0.05）. No adverse reaction was observed in both groups. Conclusion Cefazolin sodium pentahydrate combined with omeprazole enteric-coated capsules has better clinical efficacy than single use of omeprazole in treating duodenal ulcer.

关 键 词：十二指肠炎性溃疡 五水头孢唑啉钠 奥美拉唑肠溶胶囊 

分 类 号：R574.5[医药卫生—消化系统]