图形视网膜电图在黄斑部疾病中应用价值的研究  

The study of the application value of graph retinal electrogram in macular disease

作　　者：张静琳[1] 吴德正[1] 李梦媛[1] 侯金佟[1] 汤云霞[1] 高汝龙[1] 梁炯基[1] 

机构地区：[1]广州爱尔眼科医院眼科,510060

出　　处：《中华眼科医学杂志（电子版）》2017年第5期211-216,共6页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：广东省医学科学技术研究基金(C2017028);广州市越秀区科技计划项目(2016-WS-010)

摘　　要：目的建立实验室图形视网膜电图(PERG)各项测量参数的医学参考值范围。采用PERG对黄斑部疾病患者的黄斑部功能改变情况进行评价。方法收集2013年1月至2014年3月于广州爱尔眼科医院就诊的21例(29只眼)黄斑病变患者及68例(68只眼)无其他眼部疾病的正常人的临床资料,进行前瞻性对照研究。将纳入研究的全部正常人作为对照组。将对照组正常人按照年龄和裸眼视力分为两个亚组。其中,裸眼视力≥1.0且年龄≥45岁者为对照A组;裸眼视力≥0.8且年龄<45岁者为对照B组。将全部黄斑部疾病患者作为黄斑部疾病组。将黄斑部疾病组患者按照年龄和最佳矫正视力分为两个亚组。其中,最佳矫正视力≥0.1且年龄<45岁者为黄斑A组;最佳矫正视力≥0.1且年龄≥45岁者为黄斑B组。对照组正常人和黄斑部疾病组患者均行相同的PERG检测,记录全部受检者N_(35)波、P_(50)波及N_(95)波潜伏期和P_(50)波及N_(95)波振幅等PERG测量参数。分别将对照组正常人的2个年龄组各项PERG测量参数的2.5%~97.5%百分位数作为本实验室的医学参考值范围。计算黄斑部疾病组患者各项PERG测量参数的异常率。对照组和黄斑部疾病组患者PERG各项测量参数采用中位数和2.5%~97.5%百分位数进行描述。对照组和黄斑部疾病组对应年龄组PERG各项测量参数的组间比较采用Mann-Whitney检验。结果经检验,本实验室PERG各项测量参数的医学参考值范围如下。对照A组的N_(35)波、P_(50)波及N_(95)波的潜伏期分别为29.00~32.50 ms、50.00~58.40 ms及93.50~112.90 ms,P_(50)波及N_(95)波的振幅分别为1.14~3.30μV及3.41~9.61μV;对照B组的N_(35)波、P_(50)波及N_(95)波的潜伏期分别为25.10~31.90 ms、48.10~56.00 ms及90.30~110.00 ms,P_(50)波及N_(95)波的振幅分别为3.86~8.77μV及4.93~11.78μV。黄斑A组患者N_(35)波、P_(50)波及N_(95)波的潜伏期和P_(50)波及N_(95)波的振幅的异常率分别为85Objective To establish the medical reference range of pattern electroretinogram（ PERG） measurement parameters in our laboratory. To evaluate the changes of macular function in patients with macular diseases by PERG. Methods The clinical data of 21 cases（ 29 eyes） with maculopathy who have visited Guang zhou Aier Eye Hospital and 68 cases（ 68 eyes） with normal eyes and no other ocular diseases were collected from January 2013 to March 2014 for our prospective controlled study. All normal subjects were included in the control group. The control group was divided into two subgroups according to age and naked vision. The naked vision ≥ 1 and 45 years of age or older subjects were divided into ≥45 years old group; the naked vision ≥0.8 and younger than 45 years subjects were divided into 45 years old group. All patients with maculopathy were treated as macular disease group. Patients with maculopathy were divided into two subgroups according to age and best corrected visual acuity. Among them,the best corrected visual ≥0.1 and younger than 45 years patients were divided into 45 years old group; the best corrected visual ≥0.1 and 45 years of age or older subjects were divided into ≥45 years old group. Normal subjects in the control group and the patients with maculopathy were detected with the same PERG. The PERG measurement parameters of peak latency of N35 wave,P50 wave and N95 wave and the peak amplitude of P50 wave and N95 wave were recorded for all subjects. The 2.5% ~ 97.5% percentile of each measurement parameters of 2 age groups in the control group were used as the medical reference range of PERG in our laboratory. Abnormal rate of PERG measurement parameters in patients with maculopathy were calculated.PERG measurement parameters of normal subjects in the control group and patients in the macular disease group were described by median and 2. 5% ~ 97. 5% percentile. PERG measurement parameters between control group and macular disease group in corresponding age group were compared using

关 键 词：黄斑 图形视网膜电图 电生理 

分 类 号：R774.5[医药卫生—眼科]