A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels  

作　　者：Yesim Coskun Ceyhun Dalkan Ozge Yabas Ozlem Onay Demirel Elif Samiye Bayar Sibel Sakarya Tuba Muftuoglu Dilaver Ersanli Nerin Bahceciler ipek Akman 

机构地区：[1]Department of Pedialrics, Bahcesehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey [2]Department of Pediatrics, Division of Neonatology, Near East University, Nicosia 99138, North Cyprus [3]Department of Ophtalmotology, Bahce~ehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey [4]Department of Biochemistry, Bahcesehir University Medical Faculty, Medical Park Goztepe Hospital, Istanbul 34732, Turkey [5]Department of Public Health, Marmara University Medical Faculty, Istanbu 134890, Turkey [6]Department of Biochemistry, GATA Haydarpa~a Hospital, Istanbul 34668, Turkey [7]Department of Ophtalmotology, GATA Haydarpasa Hospital, Istanbu134668, Turkey [8]Department of Pediatrics, Near East University, Nicosia 99138, North Cyprus

出　　处：《International Journal of Ophthalmology(English edition)》2017年第11期1722-1727,共6页国际眼科杂志（英文版）

摘　　要：AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.AIM：To detect the impact of insulin-like growth factor-1（IGF-1）and other risk factors for the early prediction of retinopathy of prematurity（ROP）and to establish a scoring system for ROP prediction by using clinical criteria and serum IGF-1 levels.METHODS：The study was conducted with 127 preterm infants.IGF-1 levels in the 1st day of life,1st,2nd,3rd and4th week of life was analyzed.The score was established after logistic regression analysis,considering the impact of each variable on the occurrences of any stage ROP.A validation cohort containing 107 preterm infants was included in the study and the predictive ability of ROP score was calculated.RESULTS：Birth weights（BW）,gestational weeks（GW）and the prevalence of breast milk consumption were lower,respiratory distress syndrome（RDS）,bronchopulmonarydysplasia（BPD）and necrotizing enterocolitis（NEC）were more frequent,the duration of mechanical ventilation and oxygen supplementation was longer in patients with ROP（P〈0.05）.Initial serum IGF-1 levels tended to be lower in newborns who developed ROP.Logistic regression analysis revealed that low BW（〈1250 g）,presence of intraventricular hemorrhage（IVH）and formula feeding increased the risk of ROP.Afterwards,the scoring system was validated on 107 infants.The negative predictive values of a score less than 4 were 84.3%,74.7%and 79.8%while positive predictive values were 76.3%,65.5%and71.6%respectively.CONCLUSION：In addition to BW〈1250 g and IVH,formula consumption was detected as a risk factor for the development of ROP.Breastfeeding is important for prevention of ROP in preterm infants.

关 键 词：ROP A predictive score for retinopathy of prematurity by using clinical risk factors and serum insulin-like growth factor-1 levels IVH IGF 

分 类 号：R77[医药卫生—眼科]